Fetal and Neonatal Exposure to Nicotine Disrupts Postnatal Lung Development in Rats: Role of VEGF and Its Receptors
| Autor: | Maria A. Petre, Alison C. Holloway, Jim Petrik, Mark D. Inman, Russ Ellis, N. Renée Labiris |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Nicotine medicine.medical_specialty Offspring medicine.medical_treatment Toxicology Article Fetus Pregnancy Internal medicine medicine Animals Weaning Rats Wistar Lung Perinatal Exposure business.industry respiratory system medicine.disease Rats Receptors Vascular Endothelial Growth Factor Endocrinology medicine.anatomical_structure Animals Newborn Prenatal Exposure Delayed Effects Smoking cessation Female business Signal Transduction medicine.drug |
| Zdroj: | International Journal of Toxicology. 30:244-252 |
| ISSN: | 1092-874X 1091-5818 |
| DOI: | 10.1177/1091581810395332 |
| Popis: | Many women are unable to quit smoking during pregnancy and therefore are prescribed drugs, including nicotine (nicotine replacement therapy [NRT]), to aid with smoking cessation. However, the consequences to the offspring of pregnant NRT users have not been well studied. The goals of this study were to determine the consequences of fetal and neonatal exposure to nicotine on lung development and function. Female rats were exposed to nicotine for 2 weeks prior to mating until weaning. Lungs were collected from saline and nicotine-treated rats from birth to adulthood to assess postnatal lung structure and function. Although nicotine exposure altered alveolarization at weaning, an effect that resolved by adulthood, it did not affect lung function at any of the ages investigated. However, nicotine exposure significantly decreased lung vascularization. The current study suggests that perinatal exposure to nicotine alters lung development, an effect which may be mediated via decreased vascular endothelial growth factor (VEGF) signaling. |
| Databáze: | OpenAIRE |
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