Accessory proteins of the zDHHC family of S-acylation enzymes
| Autor: | Carolina Locatelli, Filip Zmuda, Christine Salaün, Juan Cabrera González, Luke H. Chamberlain |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Zinc finger 0303 health sciences Huntingtin Acylation Lipoylation Saccharomyces cerevisiae S-acylation Zinc Fingers Cell Biology Biology biology.organism_classification Cell biology RS 03 medical and health sciences 0302 clinical medicine Enzyme chemistry Palmitoylation Humans Gene Acyltransferases 030217 neurology & neurosurgery Function (biology) 030304 developmental biology |
| ISSN: | 0021-9533 |
| Popis: | Almost two decades have passed since seminal work in Saccharomyces cerevisiae identified zinc finger DHHC domain-containing (zDHHC) enzymes as S-acyltransferases. These enzymes are ubiquitous in the eukarya domain, with 23 distinct zDHHC-encoding genes in the human genome. zDHHC enzymes mediate the bulk of S-acylation (also known as palmitoylation) reactions in cells, transferring acyl chains to cysteine thiolates, and in so-doing affecting the stability, localisation and function of several thousand proteins. Studies using purified components have shown that the minimal requirements for S-acylation are an appropriate zDHHC enzyme–substrate pair and fatty acyl-CoA. However, additional proteins including GCP16 (also known as Golga7), Golga7b, huntingtin and selenoprotein K, have been suggested to regulate the activity, stability and trafficking of certain zDHHC enzymes. In this Review, we discuss the role of these accessory proteins as essential components of the cellular S-acylation system. |
| Databáze: | OpenAIRE |
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