Course of liver fibrosis in HIV-hepatitis C virus-coinfected patients depending on the response to hepatitis C therapy
| Autor: | J. A. Cartón, Belén de la Fuente, Julio Collazos, Victor Asensi |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Liver fibrosis Hepatitis C virus Biopsy Immunology HIV Infections medicine.disease_cause Gastroenterology Antiviral Agents Cohort Studies Fibrosis Virology Internal medicine Medicine Humans Longitudinal Studies Stage (cooking) medicine.diagnostic_test business.industry Coinfection virus diseases Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease digestive system diseases Surgery Infectious Diseases Treatment Outcome Elasticity Imaging Techniques Female business Cohort study |
| Zdroj: | AIDS research and human retroviruses. 29(2) |
| ISSN: | 1931-8405 |
| Popis: | To evaluate the course of liver fibrosis, 328 HIV-hepatitis C virus (HCV)-coinfected patients (210 HCV treated and 118 HCV untreated) were followed-up for 38-42 months. Liver fibrosis was assessed by biopsy or elastometry at baseline and by elastometry afterward, in addition to other noninvasive indexes. A combined liver stiffness stage (LSS) was established and evaluated over time. Eighty patients had sustained virological response (SVR) and 130 had treatment failure (TF) after a standard course of peginterferon-ribavirin therapy. LSS decreased significantly in all fibrosis indexes during HCV therapy in treated patients, but the improvement persisted only in those with SVR. At the end of study, median elastometry values suffered variations of -29%, -5.0%, and +15.4% in SVR, TF, and untreated patients, respectively. Likewise, LSS worsened in 2.5%, 33.1%, and 39% of these groups, respectively: [OR (95% CI) 19.3 (4.4-119), p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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