Obesity in Adults Is Associated With Reduced Lung Function in Metabolic Syndrome and Diabetes

Autor: Carl F. Schaefer, Fawn Yeh, Anne E. Dixon, Lyle G. Best, Susan M. Marion, Darren Calhoun, Everett R. Rhoades, Ying Zhang, Elisa T. Lee
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Spirometry
Male
medicine.medical_specialty
Vital capacity
Cardiovascular and Metabolic Risk
Endocrinology
Diabetes and Metabolism
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Pulmonary function testing
03 medical and health sciences
FEV1/FVC ratio
0302 clinical medicine
Blood serum
Risk Factors
Internal medicine
Diabetes mellitus
Internal Medicine
Diabetes Mellitus
Medicine
Humans
Obesity
Prospective Studies
Abdominal obesity
Original Research
Aged
Proportional Hazards Models
Advanced and Specialized Nursing
Metabolic Syndrome
medicine.diagnostic_test
business.industry
Middle Aged
medicine.disease
3. Good health
Respiratory Function Tests
Endocrinology
Cross-Sectional Studies
Cardiovascular Diseases
Indians
North American
Linear Models
Female
Metabolic syndrome
medicine.symptom
business
Zdroj: Diabetes Care
ISSN: 1935-5548
0149-5992
Popis: OBJECTIVE The purposes of this study were to investigate whether reduced lung function is associated with metabolic syndrome (MS) and diabetes (DM) in American Indians (AIs) and to determine whether lower pulmonary function presents before the development of DM or MS. RESEARCH DESIGN AND METHODS The Strong Heart Study (SHS) is a multicenter, prospective study of cardiovascular disease (CVD) and its risk factors among AI adults. The present analysis used lung function assessment by standard spirometry at the SHS second examination (1993–1995) in 2,396 adults free of overt lung disease or CVD, with or without DM or MS. Among MS-free/DM-free participants, the development of MS/DM at the SHS third examination (1996–1999) was investigated. RESULTS Significantly lower pulmonary function was observed for AIs with MS or DM. Impaired pulmonary function was associated with MS and DM after adjustment for age, sex, abdominal obesity, current smoking status, physical activity index, hypertension, and SHS field center. Both forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were negatively associated with insulin resistance or DM severity and with serum markers of inflammation (P < 0.05). FVC and FEV1-to-FVC ratio both predicted DM in unadjusted analyses but not when adjusted for covariates, including waist circumference. In the adjusted model, abdominal obesity predicted both MS and DM. CONCLUSIONS Reduced lung function is independently associated with MS and with DM, and impaired lung function presents before the development of MS or DM; these associations may result from the effects of obesity and inflammation.
Databáze: OpenAIRE
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