Evaluation of selected parameters of immune response to rubella virus, hepatitis B virus and varicella-zoster virus infections in children born to mothers after kidney or liver transplantation
| Autor: | Monika Szpotanska-Sikorska, Agnieszka Drozdowska-Szymczak, Bozena Kociszewska-Najman, Joanna Schreiber-Zamora, Natalia Mazanowska, Miroslaw Wielgos, Natalia Czaplinska, Beata Borek-Dzieciol, Bronisława Pietrzak |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Hepatitis B virus
Herpesvirus 3 Human medicine.medical_treatment Mothers Antibody level Liver transplantation Kidney medicine.disease_cause Immune system Pregnancy medicine Humans Child Kidney transplantation business.industry Immunity Infant Newborn Varicella zoster virus Infant Obstetrics and Gynecology Rubella virus Hepatitis B medicine.disease Liver Transplantation medicine.anatomical_structure Immunoglobulin G Prenatal Exposure Delayed Effects Pediatrics Perinatology and Child Health Immunology Female business Immunosuppressive Agents |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 35:3365-3372 |
| ISSN: | 1476-4954 1476-7058 |
| DOI: | 10.1080/14767058.2020.1818219 |
| Popis: | The immune status of children exposed prenatally to immunosuppressants is not fully understood.A single-center study evaluated possible differences in antibody levels between children prenatally exposed to immunosuppressants born to mothers after hepatic or kidney transplantation (study group) compared to children without prenatal exposure to immunosuppressants (control group). Children from the study and control group were age-matched at the time of the examination and gestational age-matched, so as to obtain similar stages of the vaccination schedule and to enable reliable comparison of the results. The selection of children was made in a 1:1 ratio. The study population, a total of 138 children, was divided according to the age of the children at the time of the study into three age groups: newborns, infants (from 29 days to 1 year) and children aged1 year. Immunoenzymatic tests were used to analyze the titers of the chickenpox virus (VZV-IgG), rubella (RuV-IgG) and hepatitis B virus (HBV, HBsAb). The studied differences were compared depending on the age group and the immunosuppressive regimen used by the pregnant mother.In neonates born to mothers after liver transplantation, significant differences were found in HBsAb levels (250 mIU/ml) compared to newborns without prenatal exposure to immunosuppressants taken by pregnant mothers (11/16, 69% vs. 4/14, 29%, respectively;Prenatal exposure to immunosuppressive therapy does not appear to affect VZV, RuV and HBV antibody levels in children of mothers who have had a kidney or liver transplant. Initially elevated HBSAb levels in newborns of mothers after liver transplantation are not observed in later stages of life. |
| Databáze: | OpenAIRE |
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