High-performance and high-sensitivity applications of graphene transistors with self-assembled monolayers
| Autor: | Vinod Kumar, Chien-Chung Chang, Po-Wen Chiu, She-Hsin Hsiao, Kun-Ping Huang, David Ricardo Moyano, Vyom Parashar, Chao-Hui Yeh, Anchal Srivastava, Preeti S. Saxena, Shao-Hsuan Wen |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Conductometry Transistors Electronic Orders of magnitude (temperature) Biomedical Engineering Biophysics Nanotechnology Biosensing Techniques 02 engineering and technology Dielectric Sensitivity and Specificity 01 natural sciences law.invention law 0103 physical sciences Monolayer Biomarkers Tumor Electrochemistry Humans 010306 general physics Immunoassay Graphene Microchemistry Antibodies Monoclonal Membrane Proteins Reproducibility of Results Self-assembled monolayer Equipment Design General Medicine Neoplastic Cells Circulating 021001 nanoscience & nanotechnology Cutoff frequency Equipment Failure Analysis Chondroitin Sulfate Proteoglycans Graphite Field-effect transistor 0210 nano-technology Graphene nanoribbons Biotechnology |
| Zdroj: | Biosensors and Bioelectronics. 77:1008-1015 |
| ISSN: | 0956-5663 |
| DOI: | 10.1016/j.bios.2015.10.078 |
| Popis: | Charge impurities and polar molecules on the surface of dielectric substrates has long been a critical obstacle to using graphene for its niche applications that involve graphene's high mobility and high sensitivity nature. Self-assembled monolayers (SAMs) have been found to effectively reduce the impact of long-range scatterings induced by the external charges. Yet, demonstrations of scalable device applications using the SAMs technique remains missing due to the difficulties in the device fabrication arising from the strong surface tension of the modified dielectric environment. Here, we use patterned SAM arrays to build graphene electronic devices with transport channels confined on the modified areas. For high-mobility applications, both rigid and flexible radio-frequency graphene field-effect transistors (G-FETs) were demonstrated, with extrinsic cutoff frequency and maximum oscillation frequency enhanced by a factor of ~2 on SiO2/Si substrates. For high sensitivity applications, G-FETs were functionalized by monoclonal antibodies specific to cancer biomarker chondroitin sulfate proteoglycan 4, enabling its detection at a concentration of 0.01 fM, five orders of magnitude lower than that detectable by a conventional colorimetric assay. These devices can be very useful in the early diagnosis and monitoring of a malignant disease. |
| Databáze: | OpenAIRE |
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