Shifting brain circuits in pain chronicity
| Autor: | Eduard Kraft, David Zurakowski, Natalia Lopez, Nadia Barakat, Monica Azqueta-Gavaldon, David Borsook, Alyssa Lebel, Farah Mahmud, Laura E. Simons, Katie E. Silva, Navil F. Sethna, Andrew M. Youssef |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Models Neurological Thalamus Sensory system Somatosensory system 050105 experimental psychology Young Adult 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Age groups Musculoskeletal Pain Connectome medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Ankle Injuries Gray Matter Child Research Articles Aged Pain Measurement Radiological and Ultrasound Technology Adult patients business.industry Functional connectivity 05 social sciences Age Factors Somatosensory Cortex Middle Aged Magnetic Resonance Imaging Reflex Sympathetic Dystrophy Regional pain Neurology Organ Specificity Case-Control Studies Sprains and Strains Disease Susceptibility Neurology (clinical) Chronic Pain Nerve Net Anatomy Ankle sprain business 030217 neurology & neurosurgery |
| Zdroj: | Hum Brain Mapp |
| ISSN: | 1097-0193 1065-9471 |
| DOI: | 10.1002/hbm.24709 |
| Popis: | The evaluation of brain changes to a specific pain condition in pediatric and adult patients allows for insights into potential mechanisms of pain chronicity and possibly long‐term brain changes. Here we focused on the primary somatosensory system (SS) involved in pain processing, namely the ventroposterolateral thalamus (VPL) and the primary somatosensory cortex (SI). We evaluated, using MRI, three specific processes: (a) somatotopy of changes in the SS for different pain origins (viz., foot vs. arm); (b) differences in acute (ankle sprain versus complex regional pain syndrome‐CRPS); and (c) differences of the effects of CRPS on SS in pediatric versus adult patients. In all cases, age‐ and sex‐matched individuals were used as controls. Our results suggest a shift in concurrent gray matter density (GMD) and resting functional connectivity strengths (rFC) across pediatric and adult CRPS with (a) differential patterns of GMD (VPL) and rFC (SI) on SS in pediatric vs. adult patterns that are consistent with upper and lower limb somatotopical organization; and (b) widespread GMD alterations in pediatric CRPS from sensory, emotional and descending modulatory processes to more confined sensory‐emotional changes in adult CRPS and rFC patterns from sensory‐sensory alterations in pediatric populations to a sensory‐emotional change in adult populations. These results support the idea that pediatric and adult CRPS are differentially represented and may reflect underlying differences in pain chronification across age groups that may contribute to the well‐known differences between child and adult pain vulnerability and resilience. |
| Databáze: | OpenAIRE |
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