Treatment of recurrent and widespread testicular tumor by radical reductive surgery and multiple sequential chemotherapy
| Autor: | Claude Merrin, Joseph Kassis, Sunmolu Beckley, Hiroshi Takita |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adult
Male Vincristine medicine.medical_specialty Cyclophosphamide Adolescent Vomiting Urology medicine.medical_treatment Antineoplastic Agents Bleomycin chemistry.chemical_compound Testicular Neoplasms Recurrence medicine Humans Psychology Choriocarcinoma Neoplasm Metastasis Chemotherapy Sequential chemotherapy business.industry Teratoma Nausea Middle Aged Hematologic Diseases Vinblastine Surgery medicine.anatomical_structure chemistry Doxorubicin Hydrochloride Abdomen Drug Therapy Combination Parenteral Nutrition Total business medicine.drug |
| Zdroj: | The Journal of urology. 117(3) |
| ISSN: | 0022-5347 |
| Popis: | There were 37 patients with stages II and III testicular tumors treated by a combination of multisequential chemotherapy and radical reductive surgery. Two protocols were used: 30 patients received bleomycin, vinblastine, platinum, doxorubicin hydrochloride, cyclophosphamide and actinomycin D (protocol A), and 7 patients received bleomycin, vinblastine, vincristine, platinum and actinomycin D (protocol B). A complete clinical remission was achieved in 19 of the 37 patients (51.3 per cent), for an average survival of 12.9 months to date. A partial clinical remission was obtained in 7 patients (18.9 per cent), for an average survival of 14.2 months. Eleven of the patients (29.7 per cent) escaped from therapeutic control. The collective response (complete and partial clinical remissions) represented 70.2 per cent of the patients (26 of 37), with an average survival of 14.8 months. A new approach for the simultaneous excision of metastases in the abdomen and the chest is described and the rational basis for the combination treatment of these tumors is discussed. |
| Databáze: | OpenAIRE |
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