Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude
| Autor: | William M. Armstead, Jason V. Gregory, Carlos H. Villa, Raisa Yu Kiseleva, Vladimir S. Shuvaev, Hamideh Parhiz, Tao Wang, Priyal Patel, Tea Shuvaeva, Jacob W. Myerson, Oscar A. Marcos-Contreras, Hugh Hekierski, Ian Johnston, Samir Mitragotri, Makan Khoshnejad, Thomas G. Uhler, Joerg Lahann, Jian-Qin Tao, Edward Cantu, Shampa Chatterjee, Kartik Bhamidipati, Vladimir R. Muzykantov, Elizabeth D. Hood, Jacob S. Brenner, Daniel C. Pan |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Lung Diseases
0301 basic medicine Erythrocytes Swine Science General Physics and Astronomy 02 engineering and technology behavioral disciplines and activities Article General Biochemistry Genetics and Molecular Biology Viral vector 03 medical and health sciences Drug Delivery Systems mental disorders medicine Animals Humans lcsh:Science Lung Drug Carriers Liposome Multidisciplinary Chemistry General Chemistry 021001 nanoscience & nanotechnology Orders of magnitude (mass) Rats 3. Good health Mice Inbred C57BL Red blood cell 030104 developmental biology medicine.anatomical_structure Drug delivery Biophysics Nanoparticles lcsh:Q Adsorption Nanocarriers 0210 nano-technology Ex vivo Artery |
| Zdroj: | Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018) Nature Communications |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-05079-7 |
| Popis: | Drug delivery by nanocarriers (NCs) has long been stymied by dominant liver uptake and limited target organ deposition, even when NCs are targeted using affinity moieties. Here we report a universal solution: red blood cell (RBC)-hitchhiking (RH), in which NCs adsorbed onto the RBCs transfer from RBCs to the first organ downstream of the intravascular injection. RH improves delivery for a wide range of NCs and even viral vectors. For example, RH injected intravenously increases liposome uptake in the first downstream organ, lungs, by ~40-fold compared with free NCs. Intra-carotid artery injection of RH NCs delivers >10% of the injected NC dose to the brain, ~10× higher than that achieved with affinity moieties. Further, RH works in mice, pigs, and ex vivo human lungs without causing RBC or end-organ toxicities. Thus, RH is a clinically translatable platform technology poised to augment drug delivery in acute lung disease, stroke, and several other diseases. Unwanted uptake in the liver and limited accumulation in target organs is a major obstacle to targeted drug delivery. Here, the authors report on the hitchhiking of nanocarriers on red blood cells and the targeted upstream delivery to different target organs in mice, pigs and ex vivo human lungs. |
| Databáze: | OpenAIRE |
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