Down-Regulated Expression of Cytokeratin 18 Promotes Progression of Human Breast Cancer
| Autor: | Ute Woelfle, Klaus Pantel, Sonja Santjer, Guido Sauter, Ruud H. Brakenhoff |
|---|---|
| Přispěvatelé: | VU University medical center |
| Rok vydání: | 2004 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Time Factors Protein Array Analysis Down-Regulation CA 15-3 Breast Neoplasms Biology Cytokeratin Breast cancer Risk Factors Biomarkers Tumor medicine Humans Lymph node Survival analysis Aged Tumor marker Tissue microarray Carcinoma Cancer Middle Aged Prognosis medicine.disease Immunohistochemistry Carcinoma Ductal Carcinoma Lobular medicine.anatomical_structure Oncology Lymphatic Metastasis Disease Progression Keratins |
| Zdroj: | Clinical Cancer Research, 10(8), 2670-4. American Association for Cancer Research Inc. Woelfle, U, Sauter, G, Santjer, S, Brakenhoff, R H & Pantel, K 2004, ' Down-regulated expression of cytokeratin 18 promotes progression of human breast cancer. ', Clinical Cancer Research, vol. 10, no. 8, pp. 2670-4 . https://doi.org/10.1158/1078-0432.CCR-03-0114 |
| ISSN: | 1557-3265 1078-0432 |
| DOI: | 10.1158/1078-0432.ccr-03-0114 |
| Popis: | Purpose: Cytokeratins (CKs) have been recognized for >20 years as structural marker proteins specific for epithelial cells. Recent expression profiling analyses indicate, however, that CK down-regulation may occur in breast cancer. Experimental Design: Here we evaluated the expression pattern of CK18 by immunohistochemical analysis of primary breast carcinomas (n = 1458) spotted on a high-density tissue microarray. The findings were correlated to histopathological risk factors and clinical outcome. Results: Down-regulation of CK18 (as compared to normal breast tissue) was observed in 25.4% of the tumors with a lower rate in lobular carcinomas (17.0%) than in ductal carcinomas (25.4%) or other histological entities (32.5%). CK down-regulation was significantly correlated to advanced tumor stage and high grade but not to axillary lymph node status. Kaplan-Meier survival analysis revealed CK18 as a prognostic indicator of overall survival (P = 0.015) and cancer-specific survival (P = 0.005). Conclusions: Down-regulation of the luminal CK18 is not rare and a clinically relevant event in breast cancer. This finding has important implications for the use of CK18 as epithelial tumor marker. The correlations with clinical follow-up suggest that CK18 might suppress tumor pro-gression. |
| Databáze: | OpenAIRE |
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