Neural substrates of anorexia nervosa patient’s deficits to decode emotional information
| Autor: | Ingo Uttner, Sabine Müller, Anne-Katharina Fladung, Ulrike M. E. Schulze, Dorothée Lulé |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Alexithymia
medicine.medical_specialty Adolescent Alexithymie Emotions Angst Audiology Anxiety 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine ddc:150 medicine Humans 0501 psychology and cognitive sciences Emotion recognition ddc:610 Pathological Depression (differential diagnoses) Affective symptoms DDC 150 / Psychology medicine.diagnostic_test Depression Brief Report 05 social sciences Anorexia nervosa medicine.disease Magnetic Resonance Imaging Facial Expression Psychiatry and Mental health Clinical Psychology Anorexia nervosa (differential diagnoses) Case-Control Studies Aversive Stimulus medicine.symptom Functional magnetic resonance imaging Psychology DDC 610 / Medicine & health 030217 neurology & neurosurgery |
| Zdroj: | Eating and Weight Disorders |
| DOI: | 10.18725/oparu-49575 |
| Popis: | Purpose The aim of the study was to define specific substrates of pathological behaviour patterns by analysing cortical activity using functional magnetic resonance imaging (fMRI) during an emotional processing task. Methods In a sample of N = 11 adolescent patients with AN (16.36 years, SD ± 1.36) and N = 11 age-matched controls, we performed a functional MRI study to detect BOLD signal changes in a 3 T MRI scanner while presenting emotional facial stimuli. Results Young people with AN presented with a generally reduced cortical activation pattern in key areas of emotion recognition for happy and fearful faces. Areas essential for control of social behaviour were associated with symptoms of depression. Conclusion Obviously, there are already indications of cortical patterns in young affected persons, which indicate a changed emotional reaction to potentially aversive stimuli in the sense of a changed top-down process of emotion avoidance. Thus, the current study provides further evidence that the disorder of anorexia nervosa is closely related to deficits in emotion processing in the early course of ontogenesis. Depressive symptoms might additionally trigger pathological behavior. Due to the small sample size, the data should be considered preliminary and require further validation. Level of evidence Level of evidence III: case–control study. publishedVersion |
| Databáze: | OpenAIRE |
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