Synthesis, in vitro binding profile, and autoradiographic analysis of [3H]-cis-3-[(2-methoxybenzyl)amino]-2-phenylpiperidine, a highly potent and selective nonpeptide substance P receptor antagonist radioligand
| Autor: | T, Rosen, T F, Seeger, S, McLean, M C, Desai, K J, Guarino, D, Bryce, K, Pratt, J, Heym, P M, Chalabi, J H, Windels |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Stereochemistry medicine.drug_class Neurokinin A Guinea Pigs Molecular Sequence Data Substance P Pharmacology Substance-P Receptor Guinea pig Radioligand Assay chemistry.chemical_compound Neurokinin-1 Receptor Antagonists Piperidines Drug Discovery Radioligand medicine Animals Amino Acid Sequence Antagonist Brain Stereoisomerism Biological activity Receptor antagonist In vitro chemistry Autoradiography Molecular Medicine |
| Zdroj: | Journal of Medicinal Chemistry. 36:3197-3201 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm00073a022 |
| Popis: | The synthesis of a highly potent and selective NK 1 receptor antagonist radioligand, [ 3 H] -cis-3-[(2-methoxybenzyl)amino]-2-phenylpiperidine (6a) is described. The in vitro binding pharmacology and autoradiographic distribution of 6a in guinea pig brain following peripheral administration are also reported |
| Databáze: | OpenAIRE |
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