Radiofrequency Irradiation Attenuates High-Mobility Group Box 1 and Toll-like Receptor Activation in Ultraviolet B–Induced Skin Inflammation
| Autor: | Donghwan Kang, Myeongjoo Son, Jung Hyun Yoon, Seyeon Oh, Hyoung Moon Kim, Kyunghee Byun |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Keratinocytes Male Pharmaceutical Science Dermatitis Analytical Chemistry 030207 dermatology & venereal diseases Mice 0302 clinical medicine Hyperpigmentation Drug Discovery Macrophage HMGB1 Protein Receptor HMGB1 Toll-like receptor biology integumentary system Chemistry Toll-Like Receptors medicine.anatomical_structure Chemistry (miscellaneous) micro needling radiofrequency Molecular Medicine Cytokines medicine.symptom Keratinocyte Ultraviolet Rays Inflammation Article lcsh:QD241-441 03 medical and health sciences lcsh:Organic chemistry In vivo skin inflammation TLR medicine Animals Humans Physical and Theoretical Chemistry Cell Proliferation PIH Epidermis (botany) Macrophages Organic Chemistry Enzyme Activation Disease Models Animal 030104 developmental biology Gene Expression Regulation biology.protein Cancer research Epidermis |
| Zdroj: | Molecules Volume 26 Issue 5 Molecules, Vol 26, Iss 1297, p 1297 (2021) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules26051297 |
| Popis: | Ultraviolet B (UVB) exposure activates various inflammatory molecules of keratinocytes in the epidermis layer. Such UVB-mediated skin inflammation leaves post-inflammatory hyperpigmentation (PIH). Reports show a close relationship between PIH and high-mobility group box 1 (HMGB1) and its receptors. General clinical treatments of PIH, such as oral medication and laser treatment, have reported side effects. Recent studies reported the effects of radiofrequency (RF) irradiation on restoring dermal collagen, modulating the dermal vasculature, and thickening the basement membrane. To validate how RF regulates the inflammatory molecules from UVB-irradiated keratinocytes, we used UVB-radiated keratinocytes and macrophages, as well as animal skin. In addition, we examined two cases of RF-irradiated skin inflammatory diseases. We validated the effects of RF irradiation on keratinocytes by measuring expression levels of HMGB1, Toll-like receptors (TLRs), and other inflammatory factors. The results show that the RF modulates UVB-radiated keratinocytes to secrete fewer inflammatory factors and also modulates the expression of macrophages from HMGB1, TLRs, and inflammatory factors. RF irradiation could alleviate inflammatory skin diseases in patients. RF irradiation can regulate the macrophage indirectly through modulating the keratinocyte and inflammatory molecules of macrophages reduced in vitro and in vivo. Although the study is limited by the low number of cases, it demonstrates that RF irradiation can regulate skin inflammation in patients. |
| Databáze: | OpenAIRE |
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