Ascending pathways that mediate cholinergic modulation of lumbar motor activity
| Autor: | Meir Cherniak, Aharon Lev-Tov, Lili Anglister |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Cholinergic Agents Lumbar vertebrae Motor Activity Biochemistry 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Calcium imaging Lumbar medicine Locomotor rhythm Animals Humans Spinal cord injury Motor Neurons Lumbar Vertebrae business.industry musculoskeletal neural and ocular physiology Central pattern generator musculoskeletal system medicine.disease Acetylcholine 030104 developmental biology medicine.anatomical_structure embryonic structures Cholinergic business Neuroscience Locomotion 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Neurochemistry. 142:82-89 |
| ISSN: | 0022-3042 |
| DOI: | 10.1111/jnc.14065 |
| Popis: | Deciphering neuronal pathways that reactivate spinal central pattern generators (CPGs) and modulate the activity of spinal motoneurons in mammals in the absence of supraspinal control is important for understanding of neural control of movement and for developing novel therapeutic approaches to improve the mobility of spinal cord injury patients. Previously, we showed that the sacral and lumbar cholinergic system could potently modulate the locomotor CPGs in newborn rodents. Here, we review these and our more recent studies of sacral relay neurons with lumbar projections to the locomotor CPGs and to lumbar motoneurons and demonstrate that sacral and lumbar cholinergic components have the capacity to control the frequency of the locomotor CPGs and at the same time the motor output of the activated lumbar motoneurons during motor behavior. A model describing the suggested ascending sacro-lumbar connectivity involved in modulation of the locomotor rhythm by sacral cholinergic components is proposed and discussed. This is an article for the special issue XVth International Symposium on Cholinergic Mechanisms. |
| Databáze: | OpenAIRE |
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