Obesity and oxidative stress in patients with different periodontal status: a case-control study

Autor: Bahattin Avci, V. E. Atabay, Müge Lütfioğlu, Eser Sakallioglu, Ahmet Aydogdu
Přispěvatelé: AYDOĞDU, AHMET, Ondokuz Mayıs Üniversitesi
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
obesity
periodontal disease
Dentistry
medicine.disease_cause
Gastroenterology
Protein Carbonylation
Gingivitis
chemistry.chemical_compound
0302 clinical medicine
Malondialdehyde
oxidative stress
Medicine
protein carbonyl
Dental Plaque Index
Gingival Crevicular Fluid
Middle Aged
Periodontics
Female
total antioxidant capacity
medicine.symptom
Periodontal Index
malondialdehyde
Adult
medicine.medical_specialty
Bleeding on probing
Enzyme-Linked Immunosorbent Assay
03 medical and health sciences
Internal medicine
Periodontal Attachment Loss
Humans
Obesity
Periodontal Diseases
business.industry
030206 dentistry
medicine.disease
Chronic periodontitis
Oxidative Stress
030104 developmental biology
Clinical attachment loss
chemistry
Case-Control Studies
Chronic Periodontitis
business
Body mass index
Oxidative stress
Biomarkers
Zdroj: Journal of periodontal research. 52(1)
ISSN: 1600-0765
Popis: AVCI, Bahattin/0000-0001-6471-6495; LUTFIOGLU, MUGE/0000-0003-1499-5902 WOS: 000393165200006 PubMed: 26932579 Background and ObjectiveObesity has become an important global health concern as obesity-associated adiposity is supposedly related to systemic immunologic and inflammatory alterations. The aim of this study was to evaluate the effects of obesity on periodontally healthy and diseased tissue according to the changes in malondialdehyde (MDA), protein carbonyl (PC) and total antioxidant capacity (TAOC) levels in gingival crevicular fluid as biomarkers of oxidative stress (OS). Material and MethodsThe study sample comprised systemically healthy normal-weight (n = 45) and obese (n = 48) adults. Obesity was diagnosed according to body mass index, waist circumference and waist/hip ratio. Periodontal status was evaluated according to plaque index, gingival index, bleeding on probing, probing depth and clinical attachment level. Participants were distributed among six groups according to obesity and periodontal status, as follows: normal weight+periodontally healthy (NH); normal weight+gingivitis (NG); normal weight+generalized chronic periodontitis (NCP); obese+periodontally healthy (OH); obese+gingivitis (OG); and obese+generalized chronic periodontitis (OCP). MDA, PC and TAOC levels were measured using ELISA. ResultsThe MDA and PC levels in gingival crevicular fluid varied among groups, as follows: NCP > NG > NH (p < 0.01) and OCP > OG > OH (p < 0.01). Conversely, the levels of TAOC in gingival crevicular fluid varied as follows: NCP < NG < NH (p < 0.01) and OCP < OG < OH (p < 0.01). Paired comparisons conducted according to periodontal status showed MDA and PC levels to be higher, and TAOC levels to be lower, in the OCP group than in the NCP group, in the OG group than in the NG group and in the OH group than in the NH group. However, only the differences between the OCP and NCP groups were significant (p < 0.01). In both obese and normal-weight individuals, clinical assessments showed significant, positive correlations with MDA and PC levels and negative correlations with TAOC levels (p < 0.01). ConclusionObesity may influence periodontal tissue destruction and disease severity by increasing the level of oxidative stress in the presence of periodontal disease.
Databáze: OpenAIRE
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