Time to Detection of Hepatitis C Virus Infection With the Xpert HCV Viral Load Fingerstick Point-of-Care Assay: Facilitating a More Rapid Time to Diagnosis
| Autor: | Beth Catlett, Marianne Martinello, David Silk, Tanya L. Applegate, Philip H Cunningham, Jason Grebely, Gregory J. Dore, Behzad Hajarizadeh, Heather Valerio, Shane Tillakeratne, Indika Jayasinghe, Andrey Verich |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Waiting time Time Factors Fingerstick Hepatitis C virus Hepacivirus medicine.disease_cause Fingers medicine Humans Immunology and Allergy Point of care Blood Specimen Collection Time to detection business.industry virus diseases Middle Aged Viral Load Hepatitis C Virology digestive system diseases Infectious Diseases Point-of-Care Testing Cohort Feasibility Studies RNA Viral Female Reagent Kits Diagnostic business Viral load Time to diagnosis |
| Zdroj: | The Journal of Infectious Diseases. 221:2043-2049 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Background Xpert HCV Viral Load Fingerstick assay (Xpert HCV VL FS) is a point-of-care test quantifying HCV RNA in Methods This study evaluated time to HCV RNA detection using the Xpert HCV VL FS assay. Fingerstick whole-blood samples were collected from participants in an observational cohort in Australia. Results In May 2018–2019, 1468 participants were enrolled, 1426 had Xpert HCV VL FS testing performed, and 1386 had a valid result. HCV RNA was detected in 23% (325/1386). Among people with undetectable HCV RNA (n = 1061), median time to result was 57 minutes. Among people with detectable HCV RNA (n = 325), median time to HCV RNA detection was 32 minutes and 80% (261/325) had a detectable HCV RNA result in ≤40 minutes. Median time to HCV RNA detection was dependent on HCV RNA level. Conclusions A quicker HCV diagnosis could be achieved by monitoring the time when HCV RNA is first detected with the Xpert HCV VL FS test, rather than HCV RNA quantification, although the current platform does not allow for this. These findings could facilitate new strategies to reduce waiting times for an HCV diagnosis and improve linkage to treatment. |
| Databáze: | OpenAIRE |
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