Cutaneous infection caused byAlternariain patients receiving tacrolimus
| Autor: | Maria M Pereiro Ferreirós, Jaime Toribio, M. Pereiro, G.S. de Hoog |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment chemical and pharmacologic phenomena Alternaria alternata Tacrolimus Organ transplantation DNA Ribosomal Spacer medicine Dermatomycoses Humans In patient Aged chemistry.chemical_classification biology business.industry Alternaria Immunosuppression Sequence Analysis DNA General Medicine biology.organism_classification Dermatology Liver Transplantation Surgery surgical procedures operative Infectious Diseases chemistry Cutaneous Phaeohyphomycosis Azole business Immunosuppressive Agents |
| Zdroj: | Medical Mycology. 42:277-282 |
| ISSN: | 1460-2709 1369-3786 |
| DOI: | 10.1080/13693780310001610047 |
| Popis: | Tacrolimus, an immunosuppressant used in organ transplant surgery, is inhibitory to some medically important fungi but also may obstruct azole monotherapy in the immunocompromised patient. We observed a case of cutaneous phaeohyphomycosis caused by Alternaria alternata in a liver transplant recipient who had been under tacrolimus immunosuppression for 6 months post-transplantation. At the onset of the infection, the patient presented with an increased whole-blood tacrolimus level. After a simple surgical excision the patient was discharged from the hospital without antifungal treatment but with an adjusted tacrolimus dosage. Literature review on fungal infections in patients receiving tacrolimus suggested these patients experience cutaneous and deep mould infections that are more frequent, severe and therapy-refractory than those seen in patients with other types of immunosuppression. |
| Databáze: | OpenAIRE |
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