Comparison of natural killer cells induced by Kunjin virus and Corynebacterium parvum with those occurring naturally in nude mice
| Autor: | D O White, R I Macfarlan, Rhodri Ceredig |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Cytotoxicity
Immunologic Immunology Mice Nude Spleen Microbiology Virus Cell Line Mice Peritoneal cavity Kunjin virus Neoplasms Cell Adhesion medicine Animals Ascitic Fluid Cytotoxic T cell Propionibacterium acnes Cytotoxicity Mice Inbred BALB C Lymphokine-activated killer cell biology biology.organism_classification Virology Molecular biology Rats Specific Pathogen-Free Organisms Killer Cells Natural Infectious Diseases medicine.anatomical_structure Cell culture Parasitology Arboviruses Research Article |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.26.3.832-836.1979 |
| Popis: | Natural killer (NK) cells are rapidly elicited in the spleen and peritoneal cavity of mice inoculated intravenously or intraperitoneally with live Kunjin virus, and more slowly in the peritoneal cavity of mice inoculated intraperitoneally with Formalin-inactivated Corynebacterium parvum. NK cells induced by either agent display cytotoxicity for a similar spectrum of syngeneic, allogeneic, and xenogeneic cultured cell lines. By contrast, the cells occurring naturally in the spleen of congenitally athymic (nude) mice show substantially lower NK activity and are cytotoxic for a more restricted range of target cell lines. The distinction suggests that there may be more than one type of NK cell or that activation enhances the cytotoxicity and perhaps broadens the range of target specificity of endogenous NK cells. |
| Databáze: | OpenAIRE |
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