Expanded principles of ethics and its implementation during COVID-19 vaccine trials: A scoping evidence based research synthesis
| Autor: | Rajni Rajgarhia, Venetia Aranha, Vaibhav Kumar, Abhishek Royal, Kedar Mehta |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Research ethics COVID-19 Vaccines Evidence-based practice SARS-CoV-2 media_common.quotation_subject Immunology Beneficence COVID-19 Mini-Review Safeguarding Clinical trial Political science Pandemic Humans Immunology and Allergy Engineering ethics Justice (ethics) Pandemics Autonomy media_common |
| Zdroj: | Hum Vaccin Immunother |
| ISSN: | 2164-554X 2164-5515 |
| DOI: | 10.1080/21645515.2021.1947101 |
| Popis: | The COVID-19 pandemic will subside only through the emergence and distribution of an efficacious vaccine. The two main aspects that should be maintained in equilibrium: the dire necessity for speedy vaccine research and the need for safeguarding the research subjects, which is of utmost concern in research ethics. This opens up a discussion of what norms to follow during the clinical trials while developing the vaccine. As of now, various companies like Moderna, Pfizer, University of Oxford, Astra-Zeneca and so on have moved beyond the safety, efficacy and immunogenic studies. This narrative review explores and discusses the key principles of ethics: a principle of autonomy, beneficence, non-maleficence, and justice along with its ten general expanded principles. Furthermore, it delves into the different types of vaccines, their mechanisms, side effects, limitations, and advantages. |
| Databáze: | OpenAIRE |
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