Does cyclosporine affect the duration of action of vecuronium in renal transplant recipients?
| Autor: | Yukiko Goda, Koichi Takita, Hiroshi Kawahigashi, Osamu Kemmotsu, Tadayoshi Ito, Hiroshi Sakamoto, Atsushi Okuyama, Hideyuki Mashio |
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| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
business.industry Significant difference respiratory system biochemical phenomena metabolism and nutrition Group A Group B Transplantation Normal renal function Anesthesiology and Pain Medicine Renal transplant Anesthesia Anesthesiology polycyclic compounds bacteria Medicine Chronic renal failure business human activities |
| Zdroj: | Journal of Anesthesia. 9 |
| ISSN: | 1438-8359 0913-8668 |
| DOI: | 10.1007/s0054050090239 |
| Popis: | The duration of action of vecuronium was tested in 41 surgical patients to evaluate whether cyclosporine modulates the action of vecuronium. The patients were divided into three groups: 12 patients with normal renal function (group A); 14 renal transplant recipients who had received cyclosporine before surgery (group B); and 15 patients with chronic renal failure undergoing surgery other than renal transplantation and who did not receive cyclosporine (group C). The times to 10% and 20% recovery of the first twitch (REC 10 and REC 20) after intravenous administration of vecuronium 0.12 mg·kg−1 were measured using an electromyogram in each group. REC 10 and REC 20 were significantly prolonged in the patients of group B (REC 10: 93±18 min, REC 20: 110±14 min) and group C (REC 10: 80±10 min, REC 20: 89±12 min) than in the patients of group A (REC 10: 39±5 min, REC 20: 45±5 min) (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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