Good Cop, Bad Cop: The Opposing Effects of Macrophage Activation State on Maintaining or Damaging Functional β-Cell Mass
| Autor: | Jeffery S. Tessem, Daelin M Jensen, Austin T Mason, Kyle V Hendricks |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Endocrinology Diabetes and Metabolism medicine.medical_treatment lcsh:QR1-502 030209 endocrinology & metabolism Review macrophage Biochemistry lcsh:Microbiology 03 medical and health sciences 0302 clinical medicine medicine cytokine Macrophage Molecular Biology geography geography.geographical_feature_category islet diabetes Chemistry Islet β-cell Cell biology 030104 developmental biology Tissue remodeling Cytokine Function (biology) Cell mass |
| Zdroj: | Metabolites, Vol 10, Iss 485, p 485 (2020) Metabolites |
| ISSN: | 2218-1989 |
| Popis: | Loss of functional β-cell mass is a hallmark of Type 1 and Type 2 Diabetes. Macrophages play an integral role in the maintenance or destruction of pancreatic β-cells. The effect of the macrophage β-cell interaction is dependent on the activation state of the macrophage. Macrophages can be activated across a spectrum, from pro-inflammatory to anti-inflammatory and tissue remodeling. The factors secreted by these differentially activated macrophages and their effect on β-cells define the effect on functional β-cell mass. In this review, the spectrum of macrophage activation is discussed, as are the positive and negative effects on β-cell survival, expansion, and function as well as the defined factors released from macrophages that impinge on functional β-cell mass. |
| Databáze: | OpenAIRE |
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