Metabolic and nutritional effects of long-term use of guar gum in the treatment of noninsulin-dependent diabetes of poor metabolic control
| Autor: | K Savolainen, O Siitonen, I Penttilä, M. I. J. Uusitupa, Markku Parviainen, M Silvasti |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Dietary Fiber Male medicine.medical_specialty Time Factors Diet therapy medicine.medical_treatment Medicine (miscellaneous) Blood Pressure Placebo Galactans Placebo group Mannans Diabetes mellitus Internal medicine Plant Gums medicine Humans Vitamin A Triglycerides Nutrition and Dietetics Guar gum business.industry Vitamin E Cholesterol HDL Non insulin dependent diabetes mellitus Middle Aged medicine.disease Surgery Zinc Cholesterol Endocrinology Diabetes Mellitus Type 2 Metabolic control analysis Female business |
| Zdroj: | The American Journal of Clinical Nutrition. 49:345-351 |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/49.2.345 |
| Popis: | Thirty-nine patients with noninsulin-dependent diabetes on oral drug treat- ment were randomly allocated to either guar gum or placebo treatments for 3 mo. After 3 mo the placebo group was switched to guar gum treatment and both groups were followed for 10 mo (open trial). No significant difference occurred in the fasting blood glucose or glycosylated hemoglobin A1 levels between the two groups at 3 mo. Serum total cholesterol level decreased in the guar gum group from 6.55 ± 1.45 to 5.69 ± 1.2 mmol/L (p < 0.001) but no changes were observed in the placebo group (6.55 ± 1.2 vs 6.26 ± 1.4 mmol/L, NS) during 3 mo. At the end ofthe open trial (n = 33), serum cholesterol was still �-7% bower than before guar gum treatment. No consistent changes occurred in serum HDL-chobesterol or triglycerides. Serum vitamin A level was slightly lowered and plasma zinc level elevated during the open trial. Serum vitamin E level was decreased only in the group switched to guar gum at 3 mo. Am JClinNutr 1989;49:345-5 1. |
| Databáze: | OpenAIRE |
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