Aspirin exacerbated respiratory disease (AERD): molecular and cellular diagnostic & prognostic approaches
| Autor: | Maliheh Naghavi, Habib Hybar, Najmaldin Saki, Mohsen Maleknia, Mana Moghaddasi, Armin Bordbar |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.drug_class Respiratory Tract Diseases Inflammation Monoclonal antibody Allergic inflammation Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Genetics Animals Humans Medicine Genetic Predisposition to Disease Molecular Biology Aspirin Polymorphism Genetic business.industry Respiratory disease General Medicine Lipid signaling Prognosis medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Immunology Disease Progression medicine.symptom business medicine.drug |
| Zdroj: | Molecular Biology Reports. 48:2703-2711 |
| ISSN: | 1573-4978 0301-4851 |
| DOI: | 10.1007/s11033-021-06240-0 |
| Popis: | Aspirin-exacerbated respiratory disease (AERD) is characterized by immune cells dysfunction. This study aimed to investigate the molecular mechanisms involved in AERD pathogenesis. Relevant literatures were identified by a PubMed search (2005-2019) of english language papers using the terms "Aspirin-exacerbated respiratory disease", "Allergic inflammation", "molecular mechanism" and "mutation". According to the significant role of inflammation in AERD development, ILC-2 is known as the most important cell in disease progression. ILC-2 produces cytokines that induce allergic reactions and also cause lipid mediators production, which activates mast cells and basophils, ultimately. Finally, Monoclonal antibody and Aspirin desensitization in patients can be a useful treatment strategy for prevention and treatment. |
| Databáze: | OpenAIRE |
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