Effect of cyclosporin A on DNA repair and cancer incidence in kidney transplant recipients
| Autor: | Avry Chagnac, Dina Zevin, Asher Korzets, Yaacov Ori, Michal Herman, Uzi Gafter, Tsipora Malachi, Talia Weinstein |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Adolescent DNA Repair DNA repair Prednisolone medicine.medical_treatment Anti-Inflammatory Agents Azathioprine In Vitro Techniques Gastroenterology Pathology and Forensic Medicine End stage renal disease Neoplasms Internal medicine Cyclosporin a Humans Medicine Dialysis Aged Dose-Response Relationship Drug business.industry Incidence Cancer General Medicine Middle Aged medicine.disease Kidney Transplantation Transplantation Immunology Cyclosporine Leukocytes Mononuclear Kidney Failure Chronic Drug Therapy Combination Female business Immunosuppressive Agents Follow-Up Studies Kidney disease medicine.drug |
| Zdroj: | Journal of Laboratory and Clinical Medicine. 137:14-20 |
| ISSN: | 0022-2143 |
| DOI: | 10.1067/mlc.2001.111469 |
| Popis: | Cancer incidence is enhanced in transplant recipients. Decreased DNA repair ability is associated with increased cancer incidence. Transplanted patients with cancer were found to have reduced DNA repair. We hypothesized that immunosuppressive therapy may impair DNA repair and thus contribute to the increased cancer incidence in transplanted patients. The objectives of this study were (1) to investigate the effect of two immunosuppressive treatment protocols on DNA repair in kidney transplant recipients; (2) to evaluate the cancer incidence in these patients; and (3) to study the in vitro effect of cyclosporin A (CsA), azathioprine, and prednisolone-separately and in various combinations-on DNA repair. Three groups were studied: (1) a control group; (2) patients treated with azathioprine and prednisone (double-therapy group); and (3) patients treated with CsA, azathioprine, and prednisone (triple-therapy group). The two patient groups did not differ in age, gender, time on dialysis before transplantation, or kidney function or in the number of acute rejections. However, the interval from transplantation to the DNA repair study was shorter in the triple-therapy group (P |
| Databáze: | OpenAIRE |
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