Diversity-Oriented Synthesis of Useful Chiral Building Blocks from D-Mannitol

Autor:	Appu Aravind, Sundarababu Baskaran, Muthukumar G. Sankar, Ponminor Senthil Kumar
Rok vydání:	2011
Předmět:	biology Chemistry Stereochemistry Organic Chemistry Acetal Iminosugar Regioselectivity Combinatorial chemistry chemistry.chemical_compound D-mannitol Reductive cleavage biology.protein Hydroxymethyl Fucosidase Physical and Theoretical Chemistry
Zdroj:	European Journal of Organic Chemistry. 2011:6980-6988
ISSN:	1434-193X
DOI:	10.1002/ejoc.201100968
Popis:	A diversity-oriented synthesis is described for functionalized chiral building blocks (i.e., 7, 9, 10, 16, and 17) and the biologically active iminosugar, fucosidase inhibitor (2S,3R,4R,5R)-2-(hydroxymethyl)-5- methylpyrrolidine-3,4-diol (22), starting from common chiral intermediate 1a which is obtained through a regioselective reductive cleavage of a bis(benzylidene) acetal. � 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Databáze:	OpenAIRE
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