Visualizing the in-vivo application of zinc in sensitive skin using reflectance confocal microscopy
| Autor: | Hye-Jin Ahn, Ji Hwoon Baek, Min Kyung Shin, Hae Jin Kim, Mahin Alamgir, Babar Rao, Hyein Ham, Young H. Lee |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Reflectance confocal microscopy Skin barrier Science chemistry.chemical_element Dermoscopy Zinc Administration Cutaneous 01 natural sciences Article Sensitive skin 010309 optics Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences Medical research 0302 clinical medicine In vivo 0103 physical sciences Stratum corneum medicine Humans Signs and symptoms Skin Transepidermal water loss Microscopy Confocal Multidisciplinary integumentary system Middle Aged Reflectivity medicine.anatomical_structure chemistry Medicine Female Biomedical engineering |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Findings obtained on objective assessments to evaluate sensitive skin do not correlate well with the symptomatology. We utilized reflectance confocal microscopy (RCM) to compare transepidermal application of zinc in sensitive and non-sensitive skin. Thirty-six subjects participated in this study. They were divided into groups based on lactic acid sting test (LAST):‘stinger’ and ‘non-stinger’; transepidermal water loss (TEWL) measurements; and sensitivity self-assessments: ‘sensitive’ and ‘non-sensitive’. RCM images were taken to visualize transepidermal application of topically-applied zinc. The intensity of zinc reflectance at different depths was measured by ImageJ software. Based on LAST scores, the ‘stinger’ group showed significantly higher reflectance of zinc at 8 µm (stratum corneum) [face (P P = 0.004)], and at 80–104 µm (dermo-epidermal junction layer) on the face. High-TEWL group showed increased zinc reflectance at 8–24 µm (tight junction layer, P reflectance of zinc at multiple depths. Structural differences are also visualized. We suggest that RCM is a useful tool for evaluating skin barrier integrity. |
| Databáze: | OpenAIRE |
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