Hindbrain Rhombic Lip Is Comprised of Discrete Progenitor Cell Populations Allocated by Pax6
| Autor: | Heather J. DiPietrantonio, Rebecca L. Landsberg, Nina L. Hunter, Rajeshwar Awatramani, Susan M. Dymecki, Carolyn I. Rodriguez, Anna F. Farago |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Mossy fiber (hippocampus)
animal structures PAX6 Transcription Factor Neuroscience(all) LIM-Homeodomain Proteins Mice Transgenic Nerve Tissue Proteins Hindbrain Wnt1 Protein Olivary Nucleus Cell fate determination Biology Mice 03 medical and health sciences Nerve Fibers 0302 clinical medicine Cell Movement Cerebellum Basic Helix-Loop-Helix Transcription Factors medicine Animals Paired Box Transcription Factors Primordium Progenitor cell Eye Proteins Rhombic lip Body Patterning 030304 developmental biology Homeodomain Proteins Afferent Pathways 0303 health sciences Stem Cells General Neuroscience Gene Expression Regulation Developmental Cell Differentiation Climbing fiber Growth Differentiation Factors Repressor Proteins Rhombencephalon medicine.anatomical_structure GDF7 Bone Morphogenetic Proteins Choroid Plexus embryonic structures Neuroscience 030217 neurology & neurosurgery Transcription Factors |
| Zdroj: | Neuron. (6):933-947 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2005.11.031 |
| Popis: | Summary The lower rhombic lip (LRL) is a germinal zone in the dorsal hindbrain productive of tangentially migrating neurons, streaming extramurally (mossy fiber neurons) or intramurally (climbing fiber neurons). Here we show that LRL territory, operationally defined by Wnt1 expression, is parceled into molecular subdomains predictive of cell fate. Progressing dorsoventrally, Lmx1a and Gdf7 expression identifies the primordium for hindbrain choroid plexus epithelial cells; Math1 , for mossy fiber neurons; and immediately ventral to Math1 yet within Wnt1 + territory, a climbing fiber primordium dominated by Ngn1 -expressing cells. Elimination of Pax6 results in expansion of this Ngn1 + progenitor pool and reduction in the Math1 + pool, with accompanying later enlargement of the climbing fiber nucleus and reductions in mossy fiber nuclei. Pax6 loss also disrupts Msx expression cell-nonautonomously, suggesting Pax6 may influence LRL progenitor identity indirectly through potentiating BMP signaling. These studies suggest that underlying the diversity and proportions of fates produced by the LRL is a precise suborganization regulated by Pax6. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|