Minor secoiridoid aglycones from the low-polarity part of the traditional Chinese herb: Swertia mileensis
| Autor: | Yun-Bao Ma, Xue-Mei Zhang, Xiao-Yan Huang, Chang-An Geng, Ji-Jun Chen |
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| Rok vydání: | 2013 |
| Předmět: |
Pharmacology
Herb medicine food.ingredient Swertia mileensis Traditional medicine Chemistry Erythrocentaurin Organic Chemistry Pharmacology toxicology swerimilegenins Regular Article Plant Science secoiridoid aglycones Toxicology anti-HBV activity Biochemistry Analytical Chemistry food Herb Plant biochemistry Food Science |
| Zdroj: | Natural Products and Bioprospecting |
| ISSN: | 2192-2209 2192-2195 |
| DOI: | 10.1007/s13659-013-0059-y |
| Popis: | Eleven new secoiridoid aglycones involving unusual C9-skeleton: swerimilegenins A-F (1–6); bis-C9-skeleton: swerimilegenin G (7); and C10-skeleton: swerimilegenins H-K (8–11), as well as six known ones, were isolated from the low-polarity part of the traditional Chinese herb medicine Swertia mileensis. Their structures were determined by extensive spectroscopic data and X-ray diffraction. Biogenetically, swerimilegenin A (1) belonged to 10-nor-secoiridoid, and swerimilegenins B-F (2–6) were 1-nor-secoiridoids. Erythrocentaurin (12) and gentiogenal (15) showed moderate anti-HBV activity on HepG 2.2.15 cell line in vitro. Electronic Supplementary Material Supplementary material is available for this article at 10.1007/s13659-013-0059-y and is accessible for authorized users. |
| Databáze: | OpenAIRE |
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