N-Acetylglucosamine: Production and Applications
| Autor: | Chia-Rui Shen, Jeen-Kuan Chen, Chao-Lin Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Pharmaceutical Science
Cosmetics Review macromolecular substances Polysaccharide chitin Acetylglucosamine chemistry.chemical_compound Hydrolysis Chitin Polysaccharides Drug Discovery N-Acetylglucosamine Monosaccharide Humans Cellulose Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 carbohydrateN-acetylglucosamine chemistry.chemical_classification Chitinases Substrate (chemistry) N-acetylglucosamine N-Acetylneuraminic Acid carbohydrates (lipids) Glucose chemistry Biochemistry lcsh:Biology (General) carbohydrate |
| Zdroj: | Marine Drugs, Vol 8, Iss 9, Pp 2493-2516 (2010) Marine Drugs |
| ISSN: | 1660-3397 |
| Popis: | N-Acetylglucosamine (GlcNAc) is a monosaccharide that usually polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit of the polymer chitin, the second most abundant carbohydrate after cellulose. In addition to serving as a component of this homogeneous polysaccharide, GlcNAc is also a basic component of hyaluronic acid and keratin sulfate on the cell surface. In this review, we discuss the industrial production of GlcNAc, using chitin as a substrate, by chemical, enzymatic and biotransformation methods. Also, newly developed methods to obtain GlcNAc using glucose as a substrate in genetically modified microorganisms are introduced. Moreover, GlcNAc has generated interest not only as an underutilized resource but also as a new functional material with high potential in various fields. Here we also take a closer look at the current applications of GlcNAc, and several new and cutting edge approaches in this fascinating area are thoroughly discussed. |
| Databáze: | OpenAIRE |
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