Effects of Oral Administration of Probiotics from Mongolian Dairy Products on the Th1 Immune Response in Mice
| Autor: | Michio Muguruma, Yukiharu Kikuchi, Masahiko Kurokawa, Masahiko Takeshita, Satoshi Kawahara, Dashnyam Bumbein, Shiro Takeda, Muneaki Hidaka, Wataru Watanabe, Hiroki Yoshida |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_treatment
Population Receptors Antigen T-Cell Administration Oral Cell Count Biology Applied Microbiology and Biotechnology Biochemistry CD49b Cell Line Analytical Chemistry Microbiology Mice Peyer's Patches Immune system Antigen Interferon medicine Animals IL-2 receptor education Molecular Biology education.field_of_study Probiotics Organic Chemistry Interleukin Mongolia General Medicine Th1 Cells Intestines Lactobacillus Cytokine Gene Expression Regulation Immunology Cytokines Female Dairy Products Spleen Biotechnology medicine.drug |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 77:1372-1378 |
| ISSN: | 1347-6947 0916-8451 |
| Popis: | We investigated 10 lactic acid bacteria strains with probiotic potential prepared from Mongolian dairy products for their ability to induce T helper type-1 (Th1) cytokine production in mouse immune cells in vitro and in vivo. Among these strains, the Lactobacillus plantarum 06CC2 strain was effective in elevating the level of interleukin (IL)-12p40 in co-culture with J774.1 cells and the levels of IL-12 and interferon (IFN)-γ in co-culture with mouse spleen cells in vitro. Oral administration of this strain augmented the gene expression of IFN-γ and IL-12p40 and enlarged the population of CD4(+), CD25(+), and CD49b(+) cells in the spleens of normal mice. It also significantly elevated the gene expression of IL-12 receptor β2 as well as IL-12p40 and IFN-γ in Peyer's patches. Thus oral administration of strain 06CC2 was effective in inducing Th1 cytokine production activating the Th1 immune response associated with intestinal immunity in normal mice. |
| Databáze: | OpenAIRE |
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