| Autor: |
Kshitij S. Jadhav, Aurélien P. Bernheim, Léa Aeschlimann, Guylène Kirschmann, Isabelle Decosterd, Alexander F. Hoffman, Carl R. Lupica, Benjamin Boutrel |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America. 119(21) |
| ISSN: |
1091-6490 |
| Popis: |
Development of self-regulatory competencies during adolescence is partially dependent on normative brain maturation. Here, we report that adolescent rats as compared to adults exhibit impulsive and compulsive-like behavioral traits, the latter being associated with lower expression of mRNA levels of the immediate early gene zif268 in the anterior insula cortex (AIC). This suggests that underdeveloped AIC function in adolescent rats could contribute to an immature pattern of interoceptive cue integration in decision making and a compulsive phenotype. In support of this, we report that layer 5 pyramidal neurons in the adolescent rat AIC are hypoexcitable and receive fewer glutamatergic synaptic inputs compared to adults. Chemogenetic activation of the AIC attenuated compulsive traits in adolescent rats supporting the idea that in early stages of AIC maturity there exists a suboptimal integration of sensory and cognitive information that contributes to inflexible behaviors in specific conditions of reward availability. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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