The effect of endothelin, neuropeptide Y, calcitonin gene-related peptide and substance P on neutrophil functions
| Autor: | Jan Palmblad, Ingiäld Hafström, Thomas Lundeberg, Bo Ringertz |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Neutrophils Physiology Calcitonin Gene-Related Peptide Neuropeptide Substance P In Vitro Techniques Granulocyte Calcitonin gene-related peptide chemistry.chemical_compound Internal medicine medicine Humans Neuropeptide Y Cell Aggregation Chemistry Endothelins Neuropeptides hemic and immune systems Chemotaxis Neuropeptide Y receptor N-Formylmethionine Leucyl-Phenylalanine Chemotaxis Leukocyte Endocrinology medicine.anatomical_structure Calcitonin Luminescent Measurements Calcium Fura-2 Endothelin receptor Oxidation-Reduction Signal Transduction |
| Zdroj: | Acta Physiologica Scandinavica. 148:341-346 |
| ISSN: | 1365-201X 0001-6772 |
| DOI: | 10.1111/j.1748-1716.1993.tb09565.x |
| Popis: | Neuropeptides are putative mediators of inflammation. At physiological concentrations substance P has been shown to prime polymorphonuclear neutrophil granulocyte (PMN) chemiluminescence (CL). In the present study we show also that both endothelin and neuropeptide Y (NPY), but not calcitonin gene-related peptide (CGRP) are able to prime PMN oxidative metabolism. At similar nanomolar concentrations SP and endothelin (but not NPY) also primed formyl-methionyl-leucyl-phenylalanine (fMLP)-induced rises of cytosolic calcium. On the other hand, NPY caused a direct and dose-related increase of cytosolic calcium concentrations. None of the mentioned neuropeptides primed PMN aggregation or directly induced CL, aggregation or chemotaxis over a wide range of concentrations (1 fM-1 microM). |
| Databáze: | OpenAIRE |
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