Thromboses and hemorrhages are common in MPN patients with high JAK2V617F allele burden

Autor: Fabrizio Fabris, Irene Bertozzi, Anna Maria Lombardi, Giulia Bogoni, Elena Duner, Giacomo Biagetti, Maria Luigia Randi
Rok vydání: 2017
Předmět:
Male
Kaplan-Meier Estimate
Gastroenterology
Myeloproliferative neoplasms
Essential
0302 clinical medicine
Polycythemia vera
Gene Frequency
Risk Factors
80 and over
Thrombocythemia
Polycythemia Vera
Aged
80 and over
Hemorrhage
JAK2V617F allele burden
Thrombosis
Adult
Aged
Alleles
Female
Humans
Janus Kinase 2
Middle Aged
Multivariate Analysis
Myeloproliferative Disorders
Primary Myelofibrosis
Proportional Hazards Models
Risk Assessment
Thrombocythemia
Essential
Mutation
Missense
Hematology
Incidence (epidemiology)
General Medicine
Quartile
030220 oncology & carcinogenesis
medicine.medical_specialty
03 medical and health sciences
Internal medicine
medicine
Allele
Myelofibrosis
Allele frequency
Essential thrombocythemia
business.industry
Proportional hazards model
medicine.disease
Surgery
Mutation
Missense
business
030215 immunology
Zdroj: Annals of Hematology. 96:1297-1302
ISSN: 1432-0584
0939-5555
DOI: 10.1007/s00277-017-3040-8
Popis: The most common causes of morbidity and mortality in myeloproliferative neoplasms (MPN) are thrombotic and hemorrhagic complications. The JAK2V617F mutation, commonly found in MPN, correlates with several clinical and laboratory characteristics even if the relevance of JAK2V617F allele burden in the natural history of these diseases is unclear. In this study we searched, a relation between thrombotic and hemorrhagic complications and JAK2V617F allele burden level in MPN patients. We evaluated 253 consecutive MPN [121 essential thrombocythemia (ET), 124 polycythemia vera (PV), and 8 primary myelofibrosis (PMF)] patients in whom the JAK2V617F allele burden was available, all studied and followed (median 8.8 years) in our department. Patients were stratified accordingly to their JAK2V617F allele burden, into four quartiles (1st25%, 2nd 26-50%, 3rd 51-75%, and 4th75%). Significantly higher incidence of thromboses (p = 0.001) and hemorrhages (p 0.001) during follow-up has been observed in higher quartiles when compared to lower ones. Thrombosis- and hemorrhage-free survivals were poorer in patients belonging to the highest quartile. Our data suggest that MPN patients with JAK2V617F allele burden higher than 75% have to be considered as high risk patients, being prone to develop thrombo-hemorrhagic complications during the disease course.
Databáze: OpenAIRE
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