Oxaliplatin regulates expression of stress ligands in ovarian cancer cells and modulates their susceptibility to natural killer cell-mediated cytotoxicity
| Autor: | See-Voon Seow, Yi-Cheng Ng, Hwee-Ling Koh, Yin-Yin Siew, Soek-Ying Neo, Si-Min Lew, Shun-Wei Lim, Hui-Chuing Yew, Wei-Guang Seetoh |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Cytotoxicity
Immunologic Chemokine Organoplatinum Compounds Immunology Antineoplastic Agents Apoptosis GPI-Linked Proteins Immunotherapy Adoptive Immune system Stress Physiological Cell Line Tumor medicine Humans Immunology and Allergy Cytotoxic T cell Ovarian Neoplasms Cisplatin biology Chemistry Histocompatibility Antigens Class I General Medicine medicine.disease Combined Modality Therapy Oxaliplatin Gene Expression Regulation Neoplastic Killer Cells Natural Receptors TNF-Related Apoptosis-Inducing Ligand Cancer cell Cancer research biology.protein Intercellular Signaling Peptides and Proteins Receptors Virus Immunogenic cell death Female Ovarian cancer medicine.drug |
| Zdroj: | International Immunology. 27:621-632 |
| ISSN: | 1460-2377 0953-8178 |
| DOI: | 10.1093/intimm/dxv041 |
| Popis: | Selected cytotoxic chemicals can provoke the immune system to recognize and destroy malignant tumors. Most of the studies on immunogenic cell death are focused on the signals that operate on a series of receptors expressed by dendritic cells to induce tumor antigen-specific T-cell responses. Here, we explored the effects of oxaliplatin, an immunogenic cell death inducer, on the induction of stress ligands and promotion of natural killer (NK) cell-mediated cytotoxicity in human ovarian cancer cells. The results indicated that treatment of tumor cells with oxaliplatin induced the production of type I interferons and chemokines and enhanced the expression of major histocompatibility complex class I-related chains (MIC) A/B, UL16-binding protein (ULBP)-3, CD155 and TNF-related apoptosis-inducing ligand (TRAIL)-R1/R2. Furthermore, oxaliplatin but not cisplatin treatment enhanced susceptibility of ovarian cancer cells to NK cell-mediated cytolysis. In addition, activated NK cells completely abrogated the growth of cancer cells that were pretreated with oxaliplatin. However, cancer cells pretreated with the same concentration of oxaliplatin alone were capable of potentiating regrowth over a period of time. These results suggest an advantage in combining oxaliplatin and NK cell-based therapy in the treatment of ovarian cancer. Further investigation on such potential combination therapy is warranted. |
| Databáze: | OpenAIRE |
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