Morphological changes in the liver and kidneys of rats subjected to terminal ileum exclusion during obstructive cholestasis
| Autor: | Geraldo M. Azevedo, Andy Petroianu, Evandro Luis de Oliveira Costa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Liver Cirrhosis medicine.medical_specialty Pathology Histology RD1-811 medicine.medical_treatment Ileum Biology Kidney Gastroenterology chemistry.chemical_compound Cholestasis Internal medicine Laparotomy medicine Animals Rats Wistar Ligature Ligation Creatinine Pruritus Anastomosis Surgical Reproducibility of Results Cholestasis Extrahepatic medicine.disease Fibrosis Rats Treatment Outcome medicine.anatomical_structure chemistry Liver Surgery Hepatic fibrosis |
| Zdroj: | Acta Cirurgica Brasileira, Vol 29, Iss 6, Pp 353-358 (2014) Acta Cirurgica Brasileira, Volume: 29, Issue: 6, Pages: 353-358, Published: JUN 2014 Acta Cirúrgica Brasileira v.29 n.6 2014 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
| ISSN: | 0102-8650 |
| Popis: | PURPOSE: To investigate the effects of ileal exclusion on hepatic and renal morphology in extra-hepatic cholestasis. METHODS: Twenty four rats were distributed into three groups. Group 1 (control) underwent laparotomy and laparorrhaphy. The animals in groups 2 and 3 underwent hepatic duct ligature and kept in cholestasis for four weeks. After this period, the rats in groups 2 and 3 underwent internal biliary derivation. In Group 3, the last ten centimeters of the terminal ileum were by passed and excluded. Four weeks later, histological and biochemical analysis were performed in all animals of the three groups. RESULTS: In Group 1, no abnormalities regarding hepatic morphology were observed. All animals from groups 2 and 3 presented hepatic fibrosis. No difference was observed between the two groups. No morphological differences in renal histology could be identified among the three groups. There were differences in AST (p |
| Databáze: | OpenAIRE |
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