Pathogenomics: an updated European Research Agenda

Autor: Martin C. J. Maiden, Arie van der Ende, Francisco García-del Portillo, Philippe Glaser, Bernt Eric Uhlin, Luis Ángel Fernández, Khalid Islam, Sun Nyunt Wai, Matthias Frosch, Thomas F. Meyer, Werner Goebel, Levente Emödy, Timo K. Korhonen, Yair Aharonowitz, M. Graciela Pucciarelli, Carmen Buchrieser, Eric Oswald, Seyed E. Hasnain, Andreas Demuth, Till T. Bachmann, Cesare Montecucco, Jonathan J. Ewbank, Julian Parkhill, Joerg Hacker, Juergen Wehland, Antonello Covacci, Gabriele Blum-Oehler, Catharina Svanborg, Eliora Z. Ron, Juergen Heesemann, Ulrich Dobrindt, Michael S. Gilmore
Přispěvatelé: Institut für Molekulare Infektionsbiologie, Julius-Maximilians-Universität Würzburg [Wurtzbourg, Allemagne] (JMU), Department of Molecular Microbiology and Biotechnology, Tel Aviv University [Tel Aviv], Division of Pathway Medicine, University of Edinburgh, Génomique des Microorganismes Pathogènes, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Novartis Vaccines, Novartis, Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention, Julius-Maximilians-Universität Würzburg (JMU), Tel Aviv University (TAU), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT), Institut für Molekulare Infektionsbiologie, Röntgenring 11, 97070 Würzburg, Germany.
Rok vydání: 2008
Předmět:
Microbiology (medical)
Knowledge management
MESH: Bacterial Infections
Ecology (disciplines)
Genomics
Human pathogen
MESH: Gene Transfer Techniques
Biology
Microbiology
03 medical and health sciences
Antigenic Diversity
Pathogenomics
Genetics
Antigenic variation
Animals
Humans
MESH: Animals
Molecular Biology
Ecology
Evolution
Behavior and Systematics
030304 developmental biology
Comparative genomics
0303 health sciences
MESH: Humans
030306 microbiology
business.industry
MESH: Genomics
Research
MESH: Host-Pathogen Interactions
Gene Transfer Techniques
Bacterial Infections
3. Good health
Biotechnology
Europe
Infectious Diseases
MESH: Research
Databases as Topic
Host-Pathogen Interactions
[SDV.IMM]Life Sciences [q-bio]/Immunology
Identification (biology)
MESH: Europe
business
MESH: Databases as Topic
Zdroj: Infection, Genetics and Evolution
Infection, Genetics and Evolution, Elsevier, 2008, 8 (3), pp.386-93. ⟨10.1016/j.meegid.2008.01.005⟩
Infection, genetics and evolution, 8(3), 386-393. Elsevier
Infection, Genetics and Evolution, 2008, 8 (3), pp.386-93. ⟨10.1016/j.meegid.2008.01.005⟩
ISSN: 1567-1348
1567-7257
DOI: 10.1016/j.meegid.2008.01.005⟩
Popis: International audience; The emerging genomic technologies and bioinformatics provide novel opportunities for studying life-threatening human pathogens and to develop new applications for the improvement of human and animal health and the prevention, treatment, and diagnosis of infections. Based on the ecology and population biology of pathogens and related organisms and their connection to epidemiology, more accurate typing technologies and approaches will lead to better means of disease control. The analysis of the genome plasticity and gene pools of pathogenic bacteria including antigenic diversity and antigenic variation results in more effective vaccines and vaccine implementation programs. The study of newly identified and uncultivated microorganisms enables the identification of new threats. The scrutiny of the metabolism of the pathogen in the host allows the identification of new targets for anti-infectives and therapeutic approaches. The development of modulators of host responses and mediators of host damage will be facilitated by the research on interactions of microbes and hosts, including mechanisms of host damage, acute and chronic relationships as well as commensalisms. The study of multiple pathogenic and non-pathogenic microbes interacting in the host will improve the management of multiple infections and will allow probiotic and prebiotic interventions. Needless to iterate, the application of the results of improved prevention and treatment of infections into clinical tests will have a positive impact on the management of human and animal disease. The Pathogenomics Research Agenda draws on discussions with experts of the Network of Excellence "EuroPathoGenomics" at the management board meeting of the project held during 18-21 April 2007, in the Villa Vigoni, Menaggio, Italy. Based on a proposed European Research Agenda in the field of pathogenomics by the ERA-NET PathoGenoMics the meeting's participants updated the established list of topics as the research agenda for the future.
Databáze: OpenAIRE
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