Use of Ultrasmall Superparamagnetic Iron Oxide Enhanced Susceptibility Weighted Imaging and Mean Vessel Density Imaging to Monitor Antiangiogenic Effects of Sorafenib on Experimental Hepatocellular Carcinoma
| Autor: | Fang Lu, Zhi-hong Han, Hongchen Gu, Shuohui Yang, Jiang Lin, Caixia Fu |
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| Rok vydání: | 2017 |
| Předmět: |
Niacinamide
Sorafenib lcsh:Medical technology Carcinoma Hepatocellular Article Subject Angiogenesis Inhibitors Ferric Compounds 030218 nuclear medicine & medical imaging Neovascularization Mice 03 medical and health sciences 0302 clinical medicine Vessel density medicine Carcinoma Animals Humans Radiology Nuclear Medicine and imaging Neovascularization Pathologic medicine.diagnostic_test business.industry Ultrasmall superparamagnetic iron oxide Phenylurea Compounds Liver Neoplasms Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging digestive system diseases lcsh:R855-855.5 030220 oncology & carcinogenesis Hepatocellular carcinoma Susceptibility weighted imaging Heterografts medicine.symptom business Nuclear medicine Research Article medicine.drug |
| Zdroj: | Contrast Media & Molecular Imaging Contrast Media & Molecular Imaging, Vol 2017 (2017) |
| ISSN: | 1555-4317 1555-4309 |
| DOI: | 10.1155/2017/9265098 |
| Popis: | We investigated effectiveness of ultrasmall superparamagnetic iron oxide enhanced susceptibility weighted imaging (USPIO-enhanced SWI) and mean vessel density imaging (Q) in monitoring antiangiogenic effects of Sorafenib on orthotopic hepatocellular carcinoma (HCC). Thirty-five HCC xenografts were established. USPIO-enhanced SWI and Q were performed on a 1.5 T MR scanner at baseline, 7, 14, and 21 days after Sorafenib treatment. Intratumoral susceptibility signal intensity (ITSS) and Q were serially measured and compared between the treated (n = 15) and control groups (n = 15). Both ITSS and Q were significantly lower in the treated group at each time point (P < 0.05). Measurements in the treated group showed that ITSS persisted at 7 days (P = 0.669) and increased at 14 and 21 days (P < 0.05), while Q significantly declined at 7 days (P = 0.028) and gradually increased at 14 and 21 days. In the treated group, significant correlation was found between Q and histologic microvessel density (MVD) (r = 0.753, P < 0.001), and ITSS correlated well with MVD (r = 0.742, P = 0.002) after excluding the data from baseline. This study demonstrated that USPIO-enhanced SWI and Q could provide novel biomarkers for evaluating antiangiogenic effects of Sorafenib on HCC. |
| Databáze: | OpenAIRE |
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