Intravascular radiation therapy with a Re-188 liquid-filled balloon in patients with in-stent restenosis
| Autor: | Ilhami Uslu, Haluk Sayman, Levent Kabasakal, Sait Sager, Servet Öztürk, Nalan Alan Selçuk, Murat Gülbaran, Çetin Önsel, Tevfik Gürmen |
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| Rok vydání: | 2010 |
| Předmět: |
Target lesion
Male medicine.medical_specialty medicine.medical_treatment Balloon Angina Restenosis Angioplasty Occlusion medicine Humans Radiology Nuclear Medicine and imaging Myocardial infarction Radioisotopes business.industry Graft Occlusion Vascular General Medicine medicine.disease Surgery Stenosis Rhenium Blood Vessels Feasibility Studies Female Stents Safety business Angioplasty Balloon Follow-Up Studies |
| Zdroj: | Nuclear medicine communications. 31(8) |
| ISSN: | 1473-5628 |
| Popis: | OBJECTIVE The aim of this study was to evaluate the feasibility and safety of intravascular radiation therapy (IVRT) using Re-188 filled balloon system in patients with in-stent stenosis. METHODS A total of 39 patients with in-stent restenosis were enrolled as the IVRT (22 patients) and control groups (17 patients) of this study after a successful coronary angioplasty. For irradiation the angioplasty balloon was replaced by a noncompliant balloon of the same diameter but 10 mm longer in length with a proximal and distal radio-opaque marker to deliver the dose of 18 Gy at 0.5 mm depth from the surface of the balloon into the vessel wall. Angiographic follow-up was performed after 6 months. RESULTS The length of the irradiated segment was between 9.14 and 22 mm and the diameter between 2.5 and 3 mm. In the IVRT group, two patients who did not receive antiplatelet therapy had myocardial infarction. Four patients who presented with stable angina earlier also had angiographically documented in-stent occlusion (two patients) and edge stenosis (two patients) of the target lesion and received angioplasty (18.1%). In the control group, three patients with recurrent angina and four asymptomatic patients had documented in-stent occlusion angiographically at 6 months and these seven patients underwent target lesion revascularization (41.2%). The overall restenosis rate in the IVRT and control groups were 23.91 and 39.86%, respectively (P=0.013). No complications were documented, except anginal pain and ST segment changes. CONCLUSION Our results indicated that the Re-188 liquid-filled balloon is feasible, safe, and effective in patients with in-stent restenosis. |
| Databáze: | OpenAIRE |
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