Effect of transdermal estrogen dose regimen for endometrial preparation of frozen-thawed embryo transfer on reproductive and obstetric outcomes
| Autor: | Jiro Fukushima, Tsuyoshi Kasai, Shuji Hirata, Tatsuyuki Ogawa, Maki Ogi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty lcsh:QH471-489 medicine.drug_class media_common.quotation_subject Single Embryo Transfer lcsh:Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences 0302 clinical medicine Transdermal estrogen lcsh:Reproduction Medicine Menstrual cycle media_common Transdermal transdermal estrogen patches Gynecology lcsh:RC648-665 030219 obstetrics & reproductive medicine endometrial preparation business.industry constant dose hormone replacement cycle Cell Biology Original Articles Embryo transfer frozen‐thawed embryo transfer Regimen 030104 developmental biology Reproductive Medicine Estrogen Original Article business Live birth |
| Zdroj: | Reproductive Medicine and Biology Reproductive Medicine and Biology, Vol 20, Iss 2, Pp 208-214 (2021) |
| ISSN: | 1445-5781 |
| Popis: | Purpose Previous studies have reported different methods of estrogen administration during endometrial preparation for frozen‐thawed embryo transfer (FET). This study aimed to investigate a beneficial regimen of transdermal estrogen administration for FET. Methods We investigated the reproductive and obstetric outcomes of FET by comparing the increasing dose (ID) group that mimics changes in serum estradiol during the menstrual cycle and the constant dose (CD) group. Transdermal patches were used for estrogen administration in both groups. In our hospital, we targeted 315 cycles of the ID group in which FET was performed in 2017 and 324 cycles of the CD group in which FET was performed in 2018. In all cases, single embryo transfer was performed. Results All were singleton pregnancies. There was no difference in clinical pregnancy rate (28.9% vs 28.2%, P =.837) and live birth rate (17.3% vs 21.4%, P =.201) between the ID and CD groups. Spontaneous abortion rate was significantly lower in the CD group than in the ID group (37.2% vs 23.0%, P =.041). There was no difference in obstetrical outcomes. Conclusions It was considered that the simple CD regimen may be more beneficial than the complicated ID regimen. |
| Databáze: | OpenAIRE |
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