Review: the cellular mechanisms underlying mammary tissue plasticity during lactation in ruminants
| Autor: | Jocelyne Guinard-Flament, C. Charton, H. Quesnel, Lucile Hervé, Laurence Finot, Vanessa Lollivier, Pierre Lacasse, Marion Boutinaud, Frederic Dessauge, Eric Chanat |
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| Přispěvatelé: | Physiologie, Environnement et Génétique pour l'Animal et les Systèmes d'Elevage [Rennes] (PEGASE), AGROCAMPUS OUEST-Institut National de la Recherche Agronomique (INRA), Sherbrooke Research and Development Centre, Agriculture and Agri-Food Canada (AAFC), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA), Agriculture and Agri-Food [Ottawa] (AAFC) |
| Rok vydání: | 2019 |
| Předmět: |
mammary gland
dairy ruminant Mammary gland review Cell Count adaptation Biology SF1-1100 Milking 03 medical and health sciences Mammary Glands Animal Lactation medicine Animals Epigenetics milk production Progenitor cell skin and connective tissue diseases production de lait Cell Proliferation 030304 developmental biology ruminant laitier 2. Zero hunger 0303 health sciences Mechanism (biology) plasticité [SDV.BA]Life Sciences [q-bio]/Animal biology 0402 animal and dairy science mécanisme cellulaire food and beverages Epithelial Cells Ruminants 04 agricultural and veterinary sciences 040201 dairy & animal science Animal culture Cell biology Dairying régime alimentaire Milk medicine.anatomical_structure DNA methylation glande mammaire Female Animal Science and Zoology sense organs Stem cell fréquence de traite |
| Zdroj: | Animal, Vol 13, Iss, Pp s52-s64 (2019) animal animal, Cambridge University Press (CUP), 2019, 13 (S1), pp.s52-s64. ⟨10.1017/S1751731119000624⟩ animal, Published by Elsevier (since 2021) / Cambridge University Press (until 2020), 2019, 13 (S1), pp.s52-s64. ⟨10.1017/S1751731119000624⟩ Animal Animal, Published by Elsevier (since 2021) / Cambridge University Press (until 2020), 2019, 13 (S1), pp.s52-s64. ⟨10.1017/S1751731119000624⟩ |
| ISSN: | 1751-7311 1751-732X |
| Popis: | The mammary tissue is characterized by its capacity to adapt in response to a wide variety of changing conditions. This adaptation capacity is referred to as the plasticity of mammary tissue. In dairy ruminants, lactation is challenged by modifications that can either be induced on purpose, such as by modifying management practices, or occur involuntarily, when adverse environmental constraints arise. These modifications can elicit both immediate changes in milk yield and composition and carryover effects that persist after the end of the challenge. This review focuses on the current knowledge concerning the cellular mechanisms underlying mammary tissue plasticity. The main mechanisms contributing to this phenomenon are changes in the activity and number of mammary epithelial cells (MECs). Changes in the number of these cells result from variations in the rates of cell proliferation and death as well as changes in the rate MEC exfoliation. The number of MECs also depends on the number of resident adult mammary stem cells and their progenitors, which can regenerate the pools of the various mammary cells. Several challenges, including changes in milking frequency, changes in level of feed supply and hormonal manipulations, have been shown to modulate milk yield together with changes in mammary cell activity, turnover and exfoliation. Epigenetic changes may be an additional mechanism of adaptation. Indeed, changes in DNA methylation and reductions in milk yield have been observed during once-daily milking and during mastitis in dairy cows and may affect cell activity persistently. In contrast to what has been assumed for a long time, no carryover effect on milk yield were observed after feed supply challenges in dairy cows and modification of milking frequency in dairy goats, even though the number of mammary cells was affected. In addition, mammary tissue plasticity has been shown to be influenced by the stage of lactation, health status and genetic factors. In conclusion, the cellular mechanisms underlying mammary tissue plasticity are diverse, and the mammary tissue either does or does not show elastic properties (with no permanent deformation), in response to environmental changes. |
| Databáze: | OpenAIRE |
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