Nephrectomy Elicits Impact of Age and BMI on Renal Hemodynamics: Lower Postdonation Reserve Capacity in Older or Overweight Kidney Donors
| Autor: | Gerarda Navis, P. M. ter Wee, Mieneke Rook, van Willem Son, R. J. Bosma, J. J. Homan van der Heide, Rutger J. Ploeg, H. S. Hofker |
|---|---|
| Přispěvatelé: | Other departments, Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP), Nephrology, ICaR - Ischemia and repair |
| Rok vydání: | 2008 |
| Předmět: |
Male
renal hemodynamics Aging medicine.medical_treatment Overweight Kidney Nephrectomy GLOMERULAR-FILTRATION-RATE HYPERFILTRATION DISEASE Living Donors Immunology and Allergy Pharmacology (medical) donor living kidney donation glomerular filtration rate INFUSION Age Factors Middle Aged medicine.anatomical_structure Donation OBESITY Female Kidney Diseases medicine.symptom Adult medicine.medical_specialty Urinary system Urology Renal function body mass index LOW-DOSE DOPAMINE Internal medicine medicine Humans Renal hemodynamics FUNCTIONAL RESERVE Aged Transplantation HYPERTENSION business.industry renal function Hemodynamics medicine.disease Kidney Transplantation Surgery RECIPIENTS Endocrinology age renal reserve capacity Reserve capacity DONATION business Body mass index Kidney disease |
| Zdroj: | Rook, M, Bosma, R J, van Son, W J, Hofker, H S, van der Heide, J J H, ter Wee, P M, Ploeg, R J & Navis, G J 2008, ' Nephrectomy elicits impact of age and BMI on renal hemodynamics: lower postdonation reserve capacity in older or overweight kidney donors ', American Journal of Transplantation, vol. 8, no. 10, pp. 2077-2085 . https://doi.org/10.1111/j.1600-6143.2008.02355.x American journal of transplantation, 8(10), 2077-2085. Wiley-Blackwell American Journal of Transplantation, 8(10), 2077-2085. Wiley American Journal of Transplantation, 8(10), 2077-2085. Wiley-Blackwell |
| ISSN: | 1600-6135 |
| DOI: | 10.1111/j.1600-6143.2008.02355.x |
| Popis: | Renal functional reserve could be relevant for the maintenance of renal function after kidney donation. Low-dose dopamine induces renal vasodilation with a rise in glomerular filtration rate (GFR) in healthy subjects and is thought to be a reflection of reserve capacity (RC). Older age and higher body mass index (BMI) may be associated with reduced RC. We therefore investigated RC in 178 consecutive living kidney donors (39% males, age 48 +/- 11 years, BMI 25.5 +/- 4.1). RC was determined as the rise in GFR ((125)I-iothalamate), 4 months before and 2 months after donor nephrectomy. Before donor nephrectomy, GFR was 114 +/- 20 mL/min, with a reduction to 72 +/- 12 mL/min after donor nephrectomy. The dopamine-induced rise in GFR of 11 +/- 10% was reduced to 5 +/- 7% after donor nephrectomy (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text