Long-range GABAergic neurons in the prefrontal cortex modulate behavior
| Autor: | Kelvin Quiñones-Laracuente, Ciorana Roman-Ortiz, Fabricio H. Do-Monte, Hector Bravo-Rivera, Christian Bravo-Rivera, Jose Rodriguez-Romaguera, Maria M. Diehl, Luis E Rosas-Vidal |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Physiology Prefrontal Cortex Striatum Behavioral neuroscience Optogenetics Biology Amygdala Nucleus Accumbens Glutamatergic mental disorders Neural Pathways Avoidance Learning medicine Animals GABAergic Neurons Prefrontal cortex General Neuroscience Electrophysiology medicine.anatomical_structure nervous system GABAergic Female Brief Communications Neuroscience psychological phenomena and processes |
| Zdroj: | Journal of Neurophysiology. 114:1357-1359 |
| ISSN: | 1522-1598 0022-3077 |
| DOI: | 10.1152/jn.00861.2014 |
| Popis: | GABAergic projections from the neocortex to subcortical structures have been poorly characterized. Using Dlxi12b–Cre mice, we found anatomical evidence for GABAergic neurons that project from the mouse medial prefrontal cortex (mPFC) to multiple subcortical targets. We used a combination of patch-clamp electrophysiology, optogenetics, and pharmacology to confirm that Dlxi12b-labeled projections from the mPFC to the nucleus accumbens (NAcc) release GABA and do not corelease glutamate. Furthermore, optogenetic stimulation of these GABAergic projections from mPFC to NAcc induces avoidance behavior in a real-time place preference task, suggesting that these long-range projecting GABAergic neurons can transmit aversive signals. Finally, we found evidence for heterogeneous histochemical and/or electrophysiological properties of long-range projecting GABAergic neurons in the mPFC. Some of these neurons were labeled in parvalbumin–Cre and vasoactive intestinal peptide–Cre mice. We also used a novel intersectional targeting strategy to label GABAergic neurons in the mPFC that project to NAcc and found that these neurons have fast-spiking properties and express parvalbumin. These results define possible functions and properties for a class of long-range projecting GABAergic neurons in the neocortex. |
| Databáze: | OpenAIRE |
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