Altered CD4+ T cell immunity in nurses occupationally exposed to viral pathogens
| Autor: | George Elias, Viggo Van Tendeloo, I. De Meester, Benson Ogunjimi, Evelien Smits, P. Van Damme, Hilde Jansens, Paul G. Thomas, Steven Heynderickx, Philippe Beutels, Aisha Souquette |
|---|---|
| Přispěvatelé: | Pediatrics |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
viruses T cell Immunology medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Immune system Immunity medicine Immunology and Allergy cytomegalovirus varicella zoster virus immune signatures immunosenescence Tetanus business.industry Toxoid Varicella zoster virus virus diseases Immunosenescence medicine.disease 030104 developmental biology medicine.anatomical_structure Human medicine business CD8 030215 immunology |
| Zdroj: | Clinical and experimental immunology |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1111/cei.13193 |
| Popis: | Summary Pathogen exposure, including but not limited to herpesviruses, moulds the shape of the immune system, both at a basal state and in response to immune challenge. However, little is known about the impact of high exposure to other viruses on baseline immune signatures and how the immune system copes with repetitive exposures to maintain a balanced functionality. Here we investigated baseline immune signatures, including detailed T cell phenotyping, antigen-specific CD4+ and CD8+ T cell responses and cytokine profile in paediatric (PED) nurses, who have high occupational exposure to viral pathogens including varicella zoster virus (VZV) and respiratory viruses, and in neonatal intensive care unit (NICU) nurses, as a control group with infrequent occupational exposure. Our results show a lower CD4+ T cell response to two VZV proteins (IE62 and gE) and to tetanus toxoid (TT) in PED nurses who are cytomegalovirus (CMV)-seronegative, compared to CMV-seronegative NICU nurses, and that the decline might be more pronounced the more sustained the exposure. This decline might be due to an attrition of VZV- and TT-specific T cells as a result of the continuous pressure on the CD4+ T cell compartment. Moreover, our data suggest that the distinct T cell phenotypes known to be associated with CMV-seropositivity might be less prominent in PED nurses compared to NICU nurses, implying a plausible attenuating effect of occupational exposure on CMV-associated immunosenescence. Overall, this pilot study reveals an impact of occupational exposure to viral pathogens on CD4+ T cell immunity and supports further investigation in a larger cohort. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|