Sudden hearing loss associated with tacrolimus in a kidney-pancreas allograft recipient
| Autor: | Yi Min Ku, Claudia Corwin, You Min Wu, David I. Min, Lawrence G. Hunsicker, Stephen C. Rayhill |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Graft Rejection medicine.medical_specialty Hearing loss medicine.medical_treatment Pancreas transplantation Tacrolimus otorhinolaryngologic diseases medicine Humans Pharmacology (medical) Kidney transplantation business.industry Audiogram Hearing Loss Sudden medicine.disease Kidney Transplantation Surgery Transplantation surgical procedures operative Anesthesia Sensorineural hearing loss Female Pancreas Transplantation medicine.symptom business Tinnitus Immunosuppressive Agents |
| Zdroj: | Pharmacotherapy. 19(7) |
| ISSN: | 0277-0008 |
| Popis: | A 38-year-old woman with type 1 diabetes underwent kidney-pancreas transplantation. Her postoperative course was complicated due to recurrent acute graft rejections and pancreatitis. After initial immunosuppression with microemulsion cyclosporine, mycophenolate mofetil, and prednisone with muromonab-CD3 induction, cyclosporine was switched to tacrolimus on day 44. The initial dosage was 5 mg twice/day, but it was gradually increased to 10 mg twice/day, aiming at 15-20 ng/ml. On day 17 of tacrolimus therapy the woman developed sudden hearing loss with tinnitus. The serum tacrolimus level was 28.3 ng/ml (therapeutic range 10-20 ng/ml) on day 20 of tacrolimus therapy, and peaked at 34.9 ng/ml on day 28. Two audiograms performed on days 28 and 29 confirmed bilateral hearing loss of 80% for speech perception, characterized as mild to moderate sensorineural hearing loss with speech reception threshold of 35 dB (normal < 20 dB) in both ears. The tacrolimus dosage was gradually reduced to 6 mg twice/day by day 36, with drug level 9.7 ng/ml, after which her hearing gradually recovered. |
| Databáze: | OpenAIRE |
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