Role of the PPAR-γ System in Normal and Tumoral Pituitary Corticotropic Cells and Adrenal Cells
| Autor: | Valentina Piccini, Michaela Luconi, Elena Rapizzi, Gabriella Nesi, Giada Poli, Monica Mangoni, Elisa Borgogni, Letizia Canu, Giulia Cantini, Massimo Mannelli, Tonino Ercolino |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Pituitary gland medicine.drug_class Endocrinology Diabetes and Metabolism Receptor expression Biology Cellular and Molecular Neuroscience Endocrinology Internal medicine medicine Humans Pituitary Neoplasms Thiazolidinedione Pituitary ACTH Hypersecretion Corticotrophs Pioglitazone Endocrine and Autonomic Systems Adrenal cortex Pituitary tumors Cushing's disease medicine.disease Adrenal Cortex Neoplasms PPAR gamma medicine.anatomical_structure Pituitary Gland Cancer cell Adrenal Cortex Thiazolidinediones Endocrine gland |
| Zdroj: | Neuroendocrinology. 92:23-27 |
| ISSN: | 1423-0194 0028-3835 |
| DOI: | 10.1159/000314312 |
| Popis: | PPAR-γ is a member of the nuclear hormone receptor superfamily of transcription factors, whose thiazolidinedione ligands (TZD) have been recently demonstrated to also possess anticancer properties in addition to their well-known insulin-sensitizer and glucose/lipid regulation activity. In this minireview, we summarize the current knowledge on PPAR-γ in normal and tumoral corticotropic pituitary and adrenal cells. The receptor expression has been shown in ACTH-secreting cells in both normal and adenomal pituitary as well as in normal and tumor adrenal cortex. Preclinical studies conducted both in vitro on tumor cells and in vivo on xenograft tumor models obtained by subcutaneous injection of cancer cells have evidenced the anticancer properties of TZD, in particular rosiglitazone (RGZ) and pioglitazone (PIO). In both pituitary and adrenocortical cancer, RGZ treatment results in inhibition of cell proliferation, through G0/G1 cell-cycle arrest and induction of cell apoptosis, leading to significant inhibition of tumor growth in the xenograft tumor models. In addition, since RGZ can reduce ACTH and corticosterone secretion in mouse corticotropic pituitary tumors, both RGZ and PIO have been used in the treatment of Cushing’s disease with variable but generally unsatisfactory results. Discrepancies in the antitumor effects of TZD observed between successful preclinical and unsuccessful clinical studies may be particularly due to differences in treatment duration and doses used. |
| Databáze: | OpenAIRE |
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