Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011-2012

Autor: Ziwei Qian, Qi Yao, Luyao Zhang, Yong Tan, Zijing Cai, Jianguo Dai, Ge Zhou, Meilin Xu, Rong-kui Hu
Rok vydání: 2019
Předmět:
Male
Metallic Lead
Physiology
Adolescents
Biochemistry
Families
0302 clinical medicine
Blood cadmium
Medicine and Health Sciences
Testosterone
Lipid Hormones
Young adult
Child
Children
0303 health sciences
Multidisciplinary
Multivariable linear regression
Environmental exposure
Nutrition Surveys
Body Fluids
Chemistry
Blood
Metals
Physical Sciences
Androgens
Medicine
Regression Analysis
Female
Anatomy
Research Article
Chemical Elements
Cadmium
National Health and Nutrition Examination Survey
Adolescent
medicine.drug_class
Science
030209 endocrinology & metabolism
03 medical and health sciences
Young Adult
Selenium
medicine
Humans
030304 developmental biology
Serum testosterone
Manganese
business.industry
Biology and Life Sciences
Androgen
Hormones
Age Groups
People and Places
Metallic Mercury
Population Groupings
business
Hormone
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 11, p e0224892 (2019)
ISSN: 1932-6203
Popis: Environmental exposure to metals is ubiquitous, but its relation to androgen hormone levels is not well understood, especially in children and adolescents. This study aimed to explore the relationship between blood metal concentrations (lead, cadmium, total mercury, selenium, and manganese) and serum total testosterone (TT) levels in 6-19-year-old children and adolescents in the National Health and Nutrition Examination Survey (NHANES) 2011-2012. Weighted multivariable linear regression models using NHANES sampling weights were employed to evaluate the association between log-transformed serum TT and each metal categories in male and female children (age 6-11years) and adolescents (age 12-19 years). We established that blood cadmium and manganese levels were associated with significantly higher serum TT levels in the female adolescents. Additionally, the blood selenium levels in male adolescents were related to significantly higher serum TT. No significant associations between blood lead or total mercury levels and TT were observed in children or adolescents of either sex. These findings suggest that environmental exposure to certain metals could affect serum TT levels in adolescents, which might have important implications for the health of adolescents. Further research is required to confirm and extend our present findings.
Databáze: OpenAIRE
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