Endothelin is an important determinant of renal function in a rat model of acute liver and renal failure
| Autor: | David Goodier, M Jarmulowicz, M Dashwood, P Milner, R Anand, Kevin Moore, D Harry, Stephen G Holt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Endothelin Receptor Antagonists
Male medicine.medical_specialty Hepatorenal Syndrome Renal cortex Galactosamine urologic and male genital diseases Statistics Nonparametric Renal Circulation Rats Sprague-Dawley Fulminant hepatic failure Hepatorenal syndrome Internal medicine Medicine Animals Antihypertensive Agents Cells Cultured Analysis of Variance Sulfonamides Endothelin-1 business.industry Endothelin receptor antagonist Osmolar Concentration Gastroenterology Bosentan medicine.disease Endothelin 1 Rats Up-Regulation Microscopy Electron medicine.anatomical_structure Endocrinology Renal pathology Renal blood flow Acute Disease business Liver and Biliary Disease Biomarkers medicine.drug |
| Popis: | Background and aims: Renal failure occurs in approximately 55% of patients with acute liver failure. We have previously shown that plasma endothelin 1 concentrations are elevated in patients with acute liver failure and the hepatorenal syndrome. There are few reported satisfactory animal models of liver failure together with functional renal failure. In this study, a rat model of acute liver failure induced by galactosamine that also develops renal failure was first characterised. This model was used to investigate the hypothesis that endothelin 1 is an important mediator involved in the pathogenesis of renal impairment that occurs in acute liver failure. Methods: Acute liver failure was induced in male Sprague-Dawley rats by intraperitoneal injection of galactosamine together with treatment with the endothelin receptor antagonist Bosentan. Twenty four hour urine collections were made using a metabolic cage. Renal blood flow was measured in anaesthetised animals. Results: This model developed renal failure and liver failure in the absence of any significant renal pathology, and with an accompanying fall in renal blood flow. Plasma concentrations of endothelin 1 were increased twofold following the onset of liver and renal failure (p |
| Databáze: | OpenAIRE |
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