Transneuronal Dpr12/DIP‐δ interactions facilitate compartmentalized dopaminergic innervation of Drosophila mushroom body axons
| Autor: | Hadas Keren-Shaul, Fabienne Reh, Hagar Meltzer, Thomas Riemensperger, Bavat Bornstein, Gideon Cummings, Oren Schuldiner, Victoria Berkun, Idan Alyagor, Eyal David, Ruth Adler |
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| Rok vydání: | 2021 |
| Předmět: |
Male
General Biochemistry Genetics and Molecular Biology Animals Genetically Modified 03 medical and health sciences 0302 clinical medicine Animals Drosophila Proteins Clustered Regularly Interspaced Short Palindromic Repeats Drosophila (subgenus) Molecular Biology Mushroom Bodies 030304 developmental biology 0303 health sciences General Immunology and Microbiology biology Dopaminergic Neurons General Neuroscience Dopaminergic Metamorphosis Biological Brain Articles biology.organism_classification Axons Cell biology Drosophila melanogaster nervous system Mutation Mushroom bodies Neuronal remodeling Immunoglobulin superfamily Female 030217 neurology & neurosurgery |
| Zdroj: | EMBO J |
| ISSN: | 1460-2075 0261-4189 |
| DOI: | 10.15252/embj.2020105763 |
| Popis: | The mechanisms controlling wiring of neuronal networks are not completely understood. The stereotypic architecture of the Drosophila mushroom body (MB) offers a unique system to study circuit assembly. The adult medial MB γ-lobe is comprised of a long bundle of axons that wire with specific modulatory and output neurons in a tiled manner, defining five distinct zones. We found that the immunoglobulin superfamily protein Dpr12 is cell-autonomously required in γ-neurons for their developmental regrowth into the distal γ4/5 zones, where both Dpr12 and its interacting protein, DIP-δ, are enriched. DIP-δ functions in a subset of dopaminergic neurons that wire with γ-neurons within the γ4/5 zone. During metamorphosis, these dopaminergic projections arrive to the γ4/5 zone prior to γ-axons, suggesting that γ-axons extend through a prepatterned region. Thus, Dpr12/DIP-δ transneuronal interaction is required for γ4/5 zone formation. Our study sheds light onto molecular and cellular mechanisms underlying circuit formation within subcellular resolution. |
| Databáze: | OpenAIRE |
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