Medical plant extracts and natural compounds with a hepatoprotective effect against damage caused by antitubercular drugs: A review
| Autor: | Gabriel Alfonso Gutiérrez-Rebolledo, Rosalba León-Díaz, Mariana Meckes-Fischer, María Adelina Jiménez-Arellanes |
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| Rok vydání: | 2016 |
| Předmět: |
Liver injury
Medicine(all) Tuberculosis business.industry Isoniazid General Medicine Pyrazinamide Pharmacology Antituberculous drugs Natural compounds medicine.disease 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Medicinal plants 030220 oncology & carcinogenesis Asian country medicine Liver damage business Hepatoprotective effect medicine.drug Antitubercular drugs-induced hepatotoxicity |
| Zdroj: | Asian Pacific journal of tropical medicine. 9(12) |
| ISSN: | 2352-4146 |
| Popis: | Drug-induced liver injury encompasses a spectrum of diseases ranging from mild biochemical abnormalities to acute liver failure; example of this scenery is hepatotoxicity caused by the first-line antituberculous drugs isoniazid, rifampin and pyrazinamide, which are basic for treatment of drug-sensible and drug-resistant tuberculosis. In the search for pharmacological alternatives to prevent liver damage, antitubercular drugs have been the subject of numerous studies and published reviews, a great majority of them carried out by Asian countries. At the same time, hepatoprotectors from plant source are now emerging as a possible alternative to counteract the toxic effects of these therapeutic agents. The present review aims to highlight the most recent studies on the subject, based information published in scientific databases such as Scopus and PubMed. |
| Databáze: | OpenAIRE |
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