Immunity Elicited by a Turkey Herpesvirus-Vectored Newcastle Disease Vaccine in Turkey Against Challenge With a Recent Genotype IV Newcastle Disease Virus Field Strain
| Autor: | Tímea Tatár-Kis, Christophe Cazaban, V. Palya, Sami Darkaoui, Abderrazak El Khantour, Tamás Mató, Amal Essalah-Bennani |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Turkeys Newcastle Disease Newcastle disease virus In ovo Newcastle disease Virus Herpesvirus 1 Meleagrid 03 medical and health sciences Food Animals Immunity medicine Animals Vector (molecular biology) Poultry Diseases Vaccines Synthetic General Immunology and Microbiology biology Viral Vaccines Vector vaccine biology.organism_classification medicine.disease Virology Immunity Innate Vaccination 030104 developmental biology Immunology Poultry disease Animal Science and Zoology |
| Zdroj: | Avian diseases. 61(3) |
| ISSN: | 1938-4351 |
| Popis: | Newcastle disease (ND) is still a major poultry disease worldwide. Vaccination remains the principal method of controlling ND in endemic countries. Various vaccination strategies, including the use of recently developed recombinant vaccines, have been used to control it. Recombinant vaccines that use the herpesvirus of turkey (HVT) as a vector to express one of the key antigens of Newcastle disease virus (NDV) have been developed to overcome some of the drawbacks related to the use of conventional vaccines. HVT as a vector appears to have unique beneficial characteristics: it is extremely safe, it is not affected by the presence of maternally derived antibodies, and therefore can be applied in the hatchery either in ovo or to day-old chicks. Due to its persistence in the bird, the HVT vector can be expected to induce life-long immune stimulation. In the present study, the efficacy of an HVT-based vector vaccine expressing the F gene of NDV (rHVT-F) was tested against a velogenic genotype IV NDV challenge in commercial turkeys with high levels of maternal antibodies (8.7 ± 0.8 log |
| Databáze: | OpenAIRE |
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